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Notch1 signaling in pyramidal neurons regulates synaptic connectivity and experience-dependent modifications of acuity in the visual cortex

Authors :
J. A. Heimel
Christiaan N. Levelt
M. H. Saiepour
Josephine M. Hermans
Huibert D. Mansvelder
Kazu Nakazawa
L. H. Van Woerden
Martijn Dahlhaus
Netherlands Institute for Neuroscience (NIN)
Integrative Neurophysiology
Center for Neurogenomics and Cognitive Research
Neuroscience Campus Amsterdam 2008
Source :
Journal of Neuroscience, 28, 10794-10802. Society for Neuroscience, Dahlhaus, M, Hermans, J M, van Woerden, L H, Saiepour, M H, Nakazawa, K, Mansvelder, H D, Heimel, J A & Levelt, C N 2008, ' Notch1 Sigaling in Pyramidal Neurons regulates Synaptic Connectivity and Experience-Dependant Modifications of acuity in the Visual Cortex ', The Journal of Neuroscience, vol. 28, no. 43, pp. 10794-10802 . https://doi.org/10.1523/JNEUROSCI.1348-08.2008, The Journal of Neuroscience, 28(43), 10794-10802. Society for Neuroscience
Publication Year :
2008

Abstract

How the visual cortex responds to specific stimuli is strongly influenced by visual experience during development. Monocular deprivation, for example, changes the likelihood of neurons in the visual cortex to respond to input from the deprived eye and reduces its visual acuity. Because these functional changes are accompanied by extensive reorganization of neurite morphology and dendritic spine turnover, genes regulating neuronal morphology are likely to be involved in visual plasticity. In recent years, Notch1 has been shown to mediate contact inhibition of neurite outgrowth in postmitotic neurons and implicated in the pathogenesis of various degenerative diseases of the CNS. Here, we provide the first evidence for the involvement of neuronal Notch1 signaling in synaptic morphology and plasticity in the visual cortex. By making use of the Cre/Lox system, we expressed an active form of Notch1 in cortical pyramidal neurons several weeks after birth. We show that neuronal Notch1 signals reduce dendritic spine and filopodia densities in a cell-autonomous manner and limit long-term potentiation in the visual cortex. After monocular deprivation, these effects of Notch1 activity predominantly affect responses to visual stimuli with higher spatial frequencies. This results in an enhanced effect of monocular deprivation on visual acuity. Copyright © 2008 Society for Neuroscience.

Details

Language :
English
ISSN :
02706474
Database :
OpenAIRE
Journal :
Journal of Neuroscience, 28, 10794-10802. Society for Neuroscience, Dahlhaus, M, Hermans, J M, van Woerden, L H, Saiepour, M H, Nakazawa, K, Mansvelder, H D, Heimel, J A & Levelt, C N 2008, ' Notch1 Sigaling in Pyramidal Neurons regulates Synaptic Connectivity and Experience-Dependant Modifications of acuity in the Visual Cortex ', The Journal of Neuroscience, vol. 28, no. 43, pp. 10794-10802 . https://doi.org/10.1523/JNEUROSCI.1348-08.2008, The Journal of Neuroscience, 28(43), 10794-10802. Society for Neuroscience
Accession number :
edsair.doi.dedup.....02ccf03b5e74c78c8084d6783a6b7b54
Full Text :
https://doi.org/10.1523/JNEUROSCI.1348-08.2008