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Notch1 signaling in pyramidal neurons regulates synaptic connectivity and experience-dependent modifications of acuity in the visual cortex
- Source :
- Journal of Neuroscience, 28, 10794-10802. Society for Neuroscience, Dahlhaus, M, Hermans, J M, van Woerden, L H, Saiepour, M H, Nakazawa, K, Mansvelder, H D, Heimel, J A & Levelt, C N 2008, ' Notch1 Sigaling in Pyramidal Neurons regulates Synaptic Connectivity and Experience-Dependant Modifications of acuity in the Visual Cortex ', The Journal of Neuroscience, vol. 28, no. 43, pp. 10794-10802 . https://doi.org/10.1523/JNEUROSCI.1348-08.2008, The Journal of Neuroscience, 28(43), 10794-10802. Society for Neuroscience
- Publication Year :
- 2008
-
Abstract
- How the visual cortex responds to specific stimuli is strongly influenced by visual experience during development. Monocular deprivation, for example, changes the likelihood of neurons in the visual cortex to respond to input from the deprived eye and reduces its visual acuity. Because these functional changes are accompanied by extensive reorganization of neurite morphology and dendritic spine turnover, genes regulating neuronal morphology are likely to be involved in visual plasticity. In recent years, Notch1 has been shown to mediate contact inhibition of neurite outgrowth in postmitotic neurons and implicated in the pathogenesis of various degenerative diseases of the CNS. Here, we provide the first evidence for the involvement of neuronal Notch1 signaling in synaptic morphology and plasticity in the visual cortex. By making use of the Cre/Lox system, we expressed an active form of Notch1 in cortical pyramidal neurons several weeks after birth. We show that neuronal Notch1 signals reduce dendritic spine and filopodia densities in a cell-autonomous manner and limit long-term potentiation in the visual cortex. After monocular deprivation, these effects of Notch1 activity predominantly affect responses to visual stimuli with higher spatial frequencies. This results in an enhanced effect of monocular deprivation on visual acuity. Copyright © 2008 Society for Neuroscience.
- Subjects :
- Silver Staining
Dendritic spine
Visual perception
Neurite
genetic structures
Dendritic Spines
Green Fluorescent Proteins
Visual Acuity
Mice, Transgenic
In Vitro Techniques
Visual system
Functional Laterality
Mice
Vision, Monocular
Cortex (anatomy)
medicine
Animals
Pseudopodia
Receptor, Notch1
Visual Cortex
Pyramidal Cells
General Neuroscience
Excitatory Postsynaptic Potentials
Long-term potentiation
Articles
eye diseases
Monocular deprivation
medicine.anatomical_structure
Visual cortex
Animals, Newborn
Synapses
sense organs
Sensory Deprivation
Psychology
Neuroscience
Photic Stimulation
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroscience, 28, 10794-10802. Society for Neuroscience, Dahlhaus, M, Hermans, J M, van Woerden, L H, Saiepour, M H, Nakazawa, K, Mansvelder, H D, Heimel, J A & Levelt, C N 2008, ' Notch1 Sigaling in Pyramidal Neurons regulates Synaptic Connectivity and Experience-Dependant Modifications of acuity in the Visual Cortex ', The Journal of Neuroscience, vol. 28, no. 43, pp. 10794-10802 . https://doi.org/10.1523/JNEUROSCI.1348-08.2008, The Journal of Neuroscience, 28(43), 10794-10802. Society for Neuroscience
- Accession number :
- edsair.doi.dedup.....02ccf03b5e74c78c8084d6783a6b7b54
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.1348-08.2008