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Age-associated systemic factors change central and peripheral immunity in adult male mice
- Source :
- Brain, Behavior, and Immunity, 111, 395-411. Academic Press Inc., van Olst, L, Kamermans, A, van der Pol, S M A, Rodríguez, E, Hulshof, L A, van Dijk, R E, Vonk, D N, Schouten, M, Witte, M E, de Vries, H E & Middeldorp, J 2023, ' Age-associated systemic factors change central and peripheral immunity in adult male mice ', Brain, Behavior, and Immunity, vol. 111, pp. 395-411 . https://doi.org/10.1016/j.bbi.2023.05.004
- Publication Year :
- 2023
-
Abstract
- Aging coincides with major changes in brain immunity that aid in a decline in neuronal function. Here, we postulate that systemic, pro-aging factors contribute to immunological changes that occur within the brain during aging. To investigate this hypothesis, we comprehensively characterized the central and peripheral immune landscape of 20-month-old male mice using cytometry by time-of-flight (CyTOF) and investigated the role of age-associated circulating factors. We found that CD8+ T cells expressing programmed cell death protein 1 (PD1) and tissue-resident memory CD8+ T cells accumulated in the aged brain while levels of memory T cells rose in the periphery. Injections of plasma derived from 20-month-old mice into 5-month-old receiving mice decreased the frequency of splenic and circulating naïve T cells, increased memory CD8+ T cells, and non-classical, patrolling monocytes in the spleen, and elevated levels of regulatory T cells and non-classical monocytes in the blood. Notably, CD8+ T cells accumulated within white matter areas of plasma-treated mice, which coincided with the expression of vascular cell adhesion molecule 1 (VCAM-1), a mediator of immune cell trafficking, on the brain vasculature. Taken together, we here describe age-related immune cell changes in the mouse brain and circulation and show that age-associated systemic factors induce the expansion of CD8+ T cells in the aged brain.
- Subjects :
- Behavioral Neuroscience
Endocrine and Autonomic Systems
Immunology
Subjects
Details
- Language :
- English
- ISSN :
- 08891591
- Database :
- OpenAIRE
- Journal :
- Brain, Behavior, and Immunity, 111, 395-411. Academic Press Inc., van Olst, L, Kamermans, A, van der Pol, S M A, Rodríguez, E, Hulshof, L A, van Dijk, R E, Vonk, D N, Schouten, M, Witte, M E, de Vries, H E & Middeldorp, J 2023, ' Age-associated systemic factors change central and peripheral immunity in adult male mice ', Brain, Behavior, and Immunity, vol. 111, pp. 395-411 . https://doi.org/10.1016/j.bbi.2023.05.004
- Accession number :
- edsair.doi.dedup.....02cf9fd7d0dd8402a372e62836fe1526