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Oxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells
- Source :
- Chemotherapy. 62(5)
- Publication Year :
- 2017
-
Abstract
- Oxytetracycline is a broad-spectrum antibiotic, but its nonantibacterial effects in the human respiratory tract are unknown. In this study, the effects of oxytetracycline on mucus secretion and inflammation were examined by PCR and ELISA in the human airway epithelial cell line NCI-H292. Oxytetracycline (10 μg/mL) significantly inhibited TNF-α-induced MUC5AC gene expression and MUC5AC protein levels in NCI-H292 cells. It also downregulated IL-8 and IL-1β gene expression and IL-1β protein levels. Our findings demonstrated that oxytetracycline suppressed mucus production and inflammation in human respiratory epithelial cells, providing further evidence for the usefulness of oxytetracycline for human airway inflammatory diseases.
- Subjects :
- 0301 basic medicine
Interleukin-1beta
Respiratory System
Down-Regulation
Inflammation
Oxytetracycline
Mucin 5AC
Microbiology
Cell Line
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Humans
Pharmacology (medical)
Secretion
Interleukin 8
Respiratory system
Pharmacology
Chemistry
Interleukin-8
NF-kappa B
Epithelial Cells
General Medicine
respiratory system
Mucus
Epithelium
Anti-Bacterial Agents
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
medicine.symptom
medicine.drug
Respiratory tract
Signal Transduction
Subjects
Details
- ISSN :
- 14219794
- Volume :
- 62
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Chemotherapy
- Accession number :
- edsair.doi.dedup.....02eacc5c0eb25c20cb849220418f0463