Additional file 1: of Control of multilayer biological networks and applied to target identification of complex diseases

Figure S1. In Pathways in cancer, the above genes are clustered near the PI3K-AKT signaling pathway. Figure S2. In Colorectal cancer pathway, the above genes are clustered near the PI3K-AKT signaling pathway and MAPK signaling pathway. Figure S3. In Apoptosis pathway, the above genes are clustered near the PI3K-AKT signaling pathway and NF-κB signaling pathway. Figure S4. In B cell receptor signaling pathway, the above genes are clustered near the PI3K-AKT signaling pathway, MAPK signaling pathway and NF-κB signaling pathway. Figure S5. In T cell receptor signaling pathway, the above genes are clustered near the MAPK signaling pathway and NF-κB signaling pathway. Figure S6. The enrichment analysis of genes from MsigDB database. Table S1. Biological functions of nodes in MFVS for three multilayer networks. Table S2. The names of drugs that AKT, P21, BCATENIN, IFNG, JAK, JUN, NFKB, IKB, PI3K, RAF, SMAD, P53 and IAP can combine with. Table S3. The drugs which ENV, GAG, NEF and GAG-POL can combine with. Table S4. Enrichment analysis of genes in MFVS of the HHMG network. Table S5. The biological information of cytokines and cell types related to cancer immune system. (PDF 626 kb)