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Human leukemic cells: Receptor binding and biological effects of insulin and insulin-like growth factors
Human leukemic cells: Receptor binding and biological effects of insulin and insulin-like growth factors
- Source :
- Leukemia Research. 10:1201-1207
- Publication Year :
- 1986
- Publisher :
- Elsevier BV, 1986.
-
Abstract
- Receptor binding and biological effects of insulin and insulin-like growth factors I and II (IGF I/II) were assessed in three human malignant cell lines: a Burkitt-type ALL-cell line, a ANLL-cell line and a Hodgkin's disease-cell line. Insulin receptor binding could be demonstrated in Burkitt-type ALL cells and ANLL cells, whereas no insulin receptor binding was detectable in Hodgkin cells. IGF I and IGF II binding could be demonstrated in all leukemic cells. Insulin stimulated glycogen synthesis in the insulin receptor bearing cell lines. DNA synthesis was stimulated by insulin, IGF I and II. IGF I was more active in stimulating DNA synthesis than IGF II.
- Subjects :
- Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Cell Line
Somatomedins
Cell surface receptor
hemic and lymphatic diseases
Insulin receptor substrate
Internal medicine
medicine
Humans
Insulin
Glycogen synthase
Leukemia
biology
DNA synthesis
Growth factor
Receptors, Somatomedin
DNA
Hematology
Receptor, Insulin
Insulin receptor
Endocrinology
Oncology
Insulin receptor binding
biology.protein
Glycogen
Subjects
Details
- ISSN :
- 01452126
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Leukemia Research
- Accession number :
- edsair.doi.dedup.....02fdb8b0208e27421cf7a0c1e1fb3282
- Full Text :
- https://doi.org/10.1016/0145-2126(86)90238-9