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Human leukemic cells: Receptor binding and biological effects of insulin and insulin-like growth factors

Human leukemic cells: Receptor binding and biological effects of insulin and insulin-like growth factors

Authors :
Jurgen Zapf
Ulrich Vetter
G. Gaedicke
W. Hartmann
Wolfgang Heit
Hans Hitzler
Eberhard Heinze
Peter V. Byrne
Jurgen H.M. Schlickenrieder
Walter M. Teller
Source :
Leukemia Research. 10:1201-1207
Publication Year :
1986
Publisher :
Elsevier BV, 1986.

Abstract

Receptor binding and biological effects of insulin and insulin-like growth factors I and II (IGF I/II) were assessed in three human malignant cell lines: a Burkitt-type ALL-cell line, a ANLL-cell line and a Hodgkin's disease-cell line. Insulin receptor binding could be demonstrated in Burkitt-type ALL cells and ANLL cells, whereas no insulin receptor binding was detectable in Hodgkin cells. IGF I and IGF II binding could be demonstrated in all leukemic cells. Insulin stimulated glycogen synthesis in the insulin receptor bearing cell lines. DNA synthesis was stimulated by insulin, IGF I and II. IGF I was more active in stimulating DNA synthesis than IGF II.

Details

ISSN :
01452126
Volume :
10
Database :
OpenAIRE
Journal :
Leukemia Research
Accession number :
edsair.doi.dedup.....02fdb8b0208e27421cf7a0c1e1fb3282
Full Text :
https://doi.org/10.1016/0145-2126(86)90238-9