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Exome-wide association study of plasma lipids in >300,000 individuals
- Source :
- Nature genetics, 49(12), 1758-1766. Nature Publishing Group, NATURE GENETICS, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Di Angelantonio, E, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-Jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Deary, I J, Dedoussis, G, Denny, J C, Dominiczak, A, Dubé, M-P, Ebeling, T, Eiriksdottir, G, Hansen, T, Jensen, G B, Jørgensen, M E & Charge Diabetes Working Group 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758–1766 . https://doi.org/10.1038/ng.3977, Nature Genetics, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Angelantonio, E DI, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-Jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y D I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Deary, I J, Dedoussis, G, Denny, J C, Dominiczak, A, Dubé, M P, Ebeling, T, Eiriksdottir, G, Esko, T, Farmaki, A E, Feitosa, M F, Ferrario, M, Ferrieres, J, Ford, I, Fornage, M, Franks, P W, Frayling, T M, Frikke-Schmidt, R, Fritsche, L G, Frossard, P, Fuster, V, Ganesh, S K, Gao, W, Garcia, M E, Gieger, C, Giulianini, F, Goodarzi, M O, Grallert, H, Grarup, N, Groop, L, Grove, M L, Gudnason, V, Hansen, T, Harris, T B, Hayward, C, Hirschhorn, J N, Holmen, O L, Huffman, J, Huo, Y, Hveem, K, Jabeen, S, Jackson, A U, Jakobsdottir, J, Jarvelin, M R, Jensen, G B, Jørgensen, M E, Jukema, J W, Justesen, J M, Kamstrup, P R, Kanoni, S, Karpe, F, Kee, F, Khera, A V, Klarin, D, Koistinen, H A, Kooner, J S, Kooperberg, C, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T, Langenberg, C, Langsted, A, Launer, L J, Lauritzen, T, MLiewald, D C, Lin, L A, Linneberg, A, Loos, R J F, Lu, Y, Lu, X, Mägi, R, Malarstig, A, Manichaikul, A, Manning, A K, Mäntyselkä, P, Marouli, E, Masca, N G D, Maschio, A, Meigs, J B, Melander, O, Metspalu, A, Morris, A P, Morrison, A C, Mulas, A, Müller-Nurasyid, M, Munroe, P B, Neville, M J, Nielsen, S F, Nielsen, J B, Nordestgaard, B G, Ordovas, J M, Mehran, R, O'Donnell, C J, Orho-Melander, M, Molony, C M, Muntendam, P, Padmanabhan, S, Palmer, C N A, Pasko, D, Patel, A P, Pedersen, O, Perola, M, Peters, A, Pisinger, C, Pistis, G, Polasek, O, Poulter, N, Psaty, B M, Rader, D J, Rasheed, A, Rauramaa, R, Reilly, D F, Reiner, A P, Renström, F, Rich, S S, Ridker, P M, Rioux, J D, Robertson, N R, Roden, D M, Rotter, J I, Rudan, I, Salomaa, V, Samani, N J, Sanna, S, Sattar, N, Schmidt, E M, Scott, R A, Sever, P, Sevilla, R S, Shaffer, C M, Sim, X, Sivapalaratnam, S, Small, K S, Smith, A V, Smith, B H, Somayajula, S, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stirrups, K E, Stitziel, N, Strauch, K, Stringham, H M, Surendran, P, Tada, H, Tall, A R, Tang, H, Tardif, J C, Taylor, K D, Trompet, S, Tsao, P S, Tuomilehto, J, Tybjaerg-Hansen, A, Zuydam, N R V, Varbo, A, Varga, T V, Virtamo, J, Waldenberger, M, Wang, N, Wareham, N J, Warren, H R, Weeke, P E, Weinstock, J, Wessel, J, Wilson, J G, Wilson, P W F, Xu, M, Yaghootkar, H, Young, R, Zeggini, E, Zhang, H, Zheng, N S, Zhang, W, Zhang, Y, Zhou, W, Zhou, Y, Zoledziewska, M, Howson, J M M, Danesh, J, McCarthy, M I, Cowan, C A, Abecasis, G, Deloukas, P, Musunuru, K, Willer, C J, Kathiresan, S & V Varga, T 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758-1766 . https://doi.org/10.1038/ng.3977, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Di Angelantonio, E, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Deary, I J, Dedoussis, G, Denny, J C, Dominiczak, A, Dubé, M, Ebeling, T, Eiriksdottir, G, Esko, T, Farmaki, A, Feitosa, M F, Ferrario, M, Ferrieres, J, Ford, I, Fornage, M, Franks, P W, Frayling, T M, Frikke-schmidt, R, Fritsche, L G, Frossard, P, Fuster, V, Ganesh, S K, Gao, W, Garcia, M E, Gieger, C, Giulianini, F, Goodarzi, M O, Grallert, H, Grarup, N, Groop, L, Grove, M L, Gudnason, V, Hansen, T, Harris, T B, Hayward, C, Hirschhorn, J N, Holmen, O L, Huffman, J, Huo, Y, Hveem, K, Jabeen, S, Jackson, A U, Jakobsdottir, J, Jarvelin, M, Jensen, G B, Jørgensen, M E, Jukema, J W, Justesen, J M, Kamstrup, P R, Kanoni, S, Karpe, F, Kee, F, Khera, A V, Klarin, D, Koistinen, H A, Kooner, J S, Kooperberg, C, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T, Langenberg, C, Langsted, A, Launer, L J, Lauritzen, T, Liewald, D C M, Lin, L A, Linneberg, A, Loos, R J F, Lu, Y, Lu, X, Mägi, R, Malarstig, A, Manichaikul, A, Manning, A K, Mäntyselkä, P, Marouli, E, Masca, N G D, Maschio, A, Meigs, J B, Melander, O, Metspalu, A, Morris, A P, Morrison, A C, Mulas, A, Müller-nurasyid, M, Munroe, P B, Neville, M J, Nielsen, J B, Nielsen, S F, Nordestgaard, B G, Ordovas, J M, Mehran, R, O'donnell, C J, Orho-melander, M, Molony, C M, Muntendam, P, Padmanabhan, S, Palmer, C N A, Pasko, D, Patel, A P, Pedersen, O, Perola, M, Peters, A, Pisinger, C, Pistis, G, Polasek, O, Poulter, N, Psaty, B M, Rader, D J, Rasheed, A, Rauramaa, R, Reilly, D F, Reiner, A P, Renström, F, Rich, S S, Ridker, P M, Rioux, J D, Robertson, N R, Roden, D M, Rotter, J I, Rudan, I, Salomaa, V, Samani, N J, Sanna, S, Sattar, N, Schmidt, E M, Scott, R A, Sever, P, Sevilla, R S, Shaffer, C M, Sim, X, Sivapalaratnam, S, Small, K S, Smith, A V, Smith, B H, Somayajula, S, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stirrups, K E, Stitziel, N, Strauch, K, Stringham, H M, Surendran, P, Tada, H, Tall, A R, Tang, H, Tardif, J, Taylor, K D, Trompet, S, Tsao, P S, Tuomilehto, J, Tybjaerg-hansen, A, Van Zuydam, N R, Varbo, A, Varga, T V, Virtamo, J, Waldenberger, M, Wang, N, Wareham, N J, Warren, H R, Weeke, P E, Weinstock, J, Wessel, J, Wilson, J G, Wilson, P W F, Xu, M, Yaghootkar, H, Young, R, Zeggini, E, Zhang, H, Zheng, N S, Zhang, W, Zhang, Y, Zhou, W, Zhou, Y, Zoledziewska, M, Howson, J M M, Danesh, J, Mccarthy, M I, Cowan, C A, Abecasis, G, Deloukas, P, Musunuru, K, Willer, C J & Kathiresan, S 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758–1766 . https://doi.org/10.1038/ng.3977, Nature Genetics, 49(12), 1758, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Di Angelantonio, E, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-Jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Grarup, N, Hansen, T, Jørgensen, M E, Lauritzen, T, Lin, L A, Nielsen, J B, Nielsen, S F, Pedersen, O, Pisinger, C, Zhang, Y & Charge Diabetes Working Group 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758-1766 . https://doi.org/10.1038/ng.3977, Nature Genetics, 49(12), 1758-1766. Nature Publishing Group, Nat. Genet. 49, 1758-1766 (2017), Nature genetics
- Publication Year :
- 2017
-
Abstract
- We screened DNA sequence variants on an exome-focused genotyping array in >300,000 participants with replication in >280,000 participants and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice revealed lipid changes consistent with the human data. We utilized mapped variants to address four clinically relevant questions and found the following: (1) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease; (2) outside of the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (3) only some mechanisms of lowering LDL-C seemed to increase risk for type 2 diabetes; and (4) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (e.g., TM6SF2, PNPLA3) tracked with higher liver fat, higher risk for type 2 diabetes, and lower risk for coronary artery disease whereas TG-lowering alleles involved in peripheral lipolysis (e.g., LPL, ANGPTL4) had no effect on liver fat but lowered risks for both type 2 diabetes and coronary artery disease.
- Subjects :
- 0301 basic medicine
Exome/genetics
Genome-wide association study
Type 2 diabetes
Coronary Artery Disease
030204 cardiovascular system & hematology
Bioinformatics
Charge Diabetes Working Group
Macular Degeneration
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Exome
Macular Degeneration/blood
Genetics & Heredity
Genetic Predisposition to Disease/genetics
CLONAL HEMATOPOIESIS
11 Medical And Health Sciences
CODING-SEQUENCE VARIANTS
Lipids
Phenotype
CARDIOVASCULAR-DISEASE
VA Million Veteran Program
lipids (amino acids, peptides, and proteins)
GOLD Consortium
LOW-FREQUENCY
EPIC-InterAct Consortium
Diabetes Mellitus, Type 2/blood
Life Sciences & Biomedicine
Type 2
medicine.medical_specialty
Genotype
APOBEC-1 COMPLEMENTATION FACTOR
Biology
Lower risk
Article
EPIC-CVD Consortium
GENETIC ARCHITECTURE
03 medical and health sciences
Coronary Artery Disease/blood
Diabetes mellitus
Internal medicine
Genetics
medicine
Diabetes Mellitus
Journal Article
Lipolysis
Humans
Genetic Predisposition to Disease
Allele
TYROSINE KINASE JAK2
Genetic Association Studies
B MESSENGER-RNA
Science & Technology
MACULAR DEGENERATION
MYELOPROLIFERATIVE DISORDERS
Cholesterol
Lipids/blood
Genetic Variation
06 Biological Sciences
medicine.disease
cardiovascular diseases
genome wide association studies
Genetic Association Studies/methods
030104 developmental biology
Endocrinology
chemistry
Diabetes Mellitus, Type 2
TM6SF2
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- Nature genetics, 49(12), 1758-1766. Nature Publishing Group, NATURE GENETICS, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Di Angelantonio, E, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-Jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Deary, I J, Dedoussis, G, Denny, J C, Dominiczak, A, Dubé, M-P, Ebeling, T, Eiriksdottir, G, Hansen, T, Jensen, G B, Jørgensen, M E & Charge Diabetes Working Group 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758–1766 . https://doi.org/10.1038/ng.3977, Nature Genetics, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Angelantonio, E DI, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-Jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y D I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Deary, I J, Dedoussis, G, Denny, J C, Dominiczak, A, Dubé, M P, Ebeling, T, Eiriksdottir, G, Esko, T, Farmaki, A E, Feitosa, M F, Ferrario, M, Ferrieres, J, Ford, I, Fornage, M, Franks, P W, Frayling, T M, Frikke-Schmidt, R, Fritsche, L G, Frossard, P, Fuster, V, Ganesh, S K, Gao, W, Garcia, M E, Gieger, C, Giulianini, F, Goodarzi, M O, Grallert, H, Grarup, N, Groop, L, Grove, M L, Gudnason, V, Hansen, T, Harris, T B, Hayward, C, Hirschhorn, J N, Holmen, O L, Huffman, J, Huo, Y, Hveem, K, Jabeen, S, Jackson, A U, Jakobsdottir, J, Jarvelin, M R, Jensen, G B, Jørgensen, M E, Jukema, J W, Justesen, J M, Kamstrup, P R, Kanoni, S, Karpe, F, Kee, F, Khera, A V, Klarin, D, Koistinen, H A, Kooner, J S, Kooperberg, C, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T, Langenberg, C, Langsted, A, Launer, L J, Lauritzen, T, MLiewald, D C, Lin, L A, Linneberg, A, Loos, R J F, Lu, Y, Lu, X, Mägi, R, Malarstig, A, Manichaikul, A, Manning, A K, Mäntyselkä, P, Marouli, E, Masca, N G D, Maschio, A, Meigs, J B, Melander, O, Metspalu, A, Morris, A P, Morrison, A C, Mulas, A, Müller-Nurasyid, M, Munroe, P B, Neville, M J, Nielsen, S F, Nielsen, J B, Nordestgaard, B G, Ordovas, J M, Mehran, R, O'Donnell, C J, Orho-Melander, M, Molony, C M, Muntendam, P, Padmanabhan, S, Palmer, C N A, Pasko, D, Patel, A P, Pedersen, O, Perola, M, Peters, A, Pisinger, C, Pistis, G, Polasek, O, Poulter, N, Psaty, B M, Rader, D J, Rasheed, A, Rauramaa, R, Reilly, D F, Reiner, A P, Renström, F, Rich, S S, Ridker, P M, Rioux, J D, Robertson, N R, Roden, D M, Rotter, J I, Rudan, I, Salomaa, V, Samani, N J, Sanna, S, Sattar, N, Schmidt, E M, Scott, R A, Sever, P, Sevilla, R S, Shaffer, C M, Sim, X, Sivapalaratnam, S, Small, K S, Smith, A V, Smith, B H, Somayajula, S, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stirrups, K E, Stitziel, N, Strauch, K, Stringham, H M, Surendran, P, Tada, H, Tall, A R, Tang, H, Tardif, J C, Taylor, K D, Trompet, S, Tsao, P S, Tuomilehto, J, Tybjaerg-Hansen, A, Zuydam, N R V, Varbo, A, Varga, T V, Virtamo, J, Waldenberger, M, Wang, N, Wareham, N J, Warren, H R, Weeke, P E, Weinstock, J, Wessel, J, Wilson, J G, Wilson, P W F, Xu, M, Yaghootkar, H, Young, R, Zeggini, E, Zhang, H, Zheng, N S, Zhang, W, Zhang, Y, Zhou, W, Zhou, Y, Zoledziewska, M, Howson, J M M, Danesh, J, McCarthy, M I, Cowan, C A, Abecasis, G, Deloukas, P, Musunuru, K, Willer, C J, Kathiresan, S & V Varga, T 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758-1766 . https://doi.org/10.1038/ng.3977, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Di Angelantonio, E, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Deary, I J, Dedoussis, G, Denny, J C, Dominiczak, A, Dubé, M, Ebeling, T, Eiriksdottir, G, Esko, T, Farmaki, A, Feitosa, M F, Ferrario, M, Ferrieres, J, Ford, I, Fornage, M, Franks, P W, Frayling, T M, Frikke-schmidt, R, Fritsche, L G, Frossard, P, Fuster, V, Ganesh, S K, Gao, W, Garcia, M E, Gieger, C, Giulianini, F, Goodarzi, M O, Grallert, H, Grarup, N, Groop, L, Grove, M L, Gudnason, V, Hansen, T, Harris, T B, Hayward, C, Hirschhorn, J N, Holmen, O L, Huffman, J, Huo, Y, Hveem, K, Jabeen, S, Jackson, A U, Jakobsdottir, J, Jarvelin, M, Jensen, G B, Jørgensen, M E, Jukema, J W, Justesen, J M, Kamstrup, P R, Kanoni, S, Karpe, F, Kee, F, Khera, A V, Klarin, D, Koistinen, H A, Kooner, J S, Kooperberg, C, Kuulasmaa, K, Kuusisto, J, Laakso, M, Lakka, T, Langenberg, C, Langsted, A, Launer, L J, Lauritzen, T, Liewald, D C M, Lin, L A, Linneberg, A, Loos, R J F, Lu, Y, Lu, X, Mägi, R, Malarstig, A, Manichaikul, A, Manning, A K, Mäntyselkä, P, Marouli, E, Masca, N G D, Maschio, A, Meigs, J B, Melander, O, Metspalu, A, Morris, A P, Morrison, A C, Mulas, A, Müller-nurasyid, M, Munroe, P B, Neville, M J, Nielsen, J B, Nielsen, S F, Nordestgaard, B G, Ordovas, J M, Mehran, R, O'donnell, C J, Orho-melander, M, Molony, C M, Muntendam, P, Padmanabhan, S, Palmer, C N A, Pasko, D, Patel, A P, Pedersen, O, Perola, M, Peters, A, Pisinger, C, Pistis, G, Polasek, O, Poulter, N, Psaty, B M, Rader, D J, Rasheed, A, Rauramaa, R, Reilly, D F, Reiner, A P, Renström, F, Rich, S S, Ridker, P M, Rioux, J D, Robertson, N R, Roden, D M, Rotter, J I, Rudan, I, Salomaa, V, Samani, N J, Sanna, S, Sattar, N, Schmidt, E M, Scott, R A, Sever, P, Sevilla, R S, Shaffer, C M, Sim, X, Sivapalaratnam, S, Small, K S, Smith, A V, Smith, B H, Somayajula, S, Southam, L, Spector, T D, Speliotes, E K, Starr, J M, Stirrups, K E, Stitziel, N, Strauch, K, Stringham, H M, Surendran, P, Tada, H, Tall, A R, Tang, H, Tardif, J, Taylor, K D, Trompet, S, Tsao, P S, Tuomilehto, J, Tybjaerg-hansen, A, Van Zuydam, N R, Varbo, A, Varga, T V, Virtamo, J, Waldenberger, M, Wang, N, Wareham, N J, Warren, H R, Weeke, P E, Weinstock, J, Wessel, J, Wilson, J G, Wilson, P W F, Xu, M, Yaghootkar, H, Young, R, Zeggini, E, Zhang, H, Zheng, N S, Zhang, W, Zhang, Y, Zhou, W, Zhou, Y, Zoledziewska, M, Howson, J M M, Danesh, J, Mccarthy, M I, Cowan, C A, Abecasis, G, Deloukas, P, Musunuru, K, Willer, C J & Kathiresan, S 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758–1766 . https://doi.org/10.1038/ng.3977, Nature Genetics, 49(12), 1758, Liu, D J, Peloso, G M, Yu, H, Butterworth, A S, Wang, X, Mahajan, A, Saleheen, D, Emdin, C, Alam, D, Alves, A C, Amouyel, P, Di Angelantonio, E, Arveiler, D, Assimes, T L, Auer, P L, Baber, U, Ballantyne, C M, Bang, L E, Benn, M, Bis, J C, Boehnke, M, Boerwinkle, E, Bork-Jensen, J, Bottinger, E P, Brandslund, I, Brown, M, Busonero, F, Caulfield, M J, Chambers, J C, Chasman, D I, Chen, Y E, Chen, Y-D I, Chowdhury, R, Christensen, C, Chu, A Y, Connell, J M, Cucca, F, Cupples, L A, Damrauer, S M, Davies, G, Grarup, N, Hansen, T, Jørgensen, M E, Lauritzen, T, Lin, L A, Nielsen, J B, Nielsen, S F, Pedersen, O, Pisinger, C, Zhang, Y & Charge Diabetes Working Group 2017, ' Exome-wide association study of plasma lipids in >300,000 individuals ', Nature Genetics, vol. 49, no. 12, pp. 1758-1766 . https://doi.org/10.1038/ng.3977, Nature Genetics, 49(12), 1758-1766. Nature Publishing Group, Nat. Genet. 49, 1758-1766 (2017), Nature genetics
- Accession number :
- edsair.doi.dedup.....030383a39967a21d7121379d9b90c713