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The VIZIER project: Preparedness against pathogenic RNA viruses
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, Antiviral Research
- Publication Year :
- 2008
- Publisher :
- Elsevier, 2008.
-
Abstract
- Coutard, B. et al.<br />Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules. © 2007 Elsevier B.V. All rights reserved.<br />This work was supported by the VIZIER integrated project (LSHG-CT-2004-511960) of the European Union 6th Framework Programme (FP6)
- Subjects :
- Models, Molecular
Proteomics
crystal structure
RNA virus
drug design
medicine.drug_class
International Cooperation
viruses
RNA-dependent RNA polymerase
Genomics
Biology
Virus Replication
Antiviral Agents
Article
Virology
Settore BIO/10 - Biochimica
medicine
Humans
RNA Viruses
Enzyme Inhibitors
Pharmacology
Genetics
Crystallography
Crystal structure
Computational Biology
RNA
RNA-Dependent RNA Polymerase
biology.organism_classification
Antivirals
Drug-design
Replicase
Structural biology
Drug Design
Preparedness
Crystal structures
RNA, Viral
Antiviral drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, Antiviral Research
- Accession number :
- edsair.doi.dedup.....032159b157d0f5bc8841a99c001e6d78