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The Kenya form of hereditary persistence of fetal haemoglobin: structural studies and evidence for homogeneous distribution of haemoglobin F using fluorescent anti-haemoglobin F antibodies
- Source :
- British journal of haematology. 32(1)
- Publication Year :
- 1976
-
Abstract
- Several members of a Ugandan family were heterozygous for the gamma beta fusion gene of Haemoglobin Kenya. Levels of Hb Kenya were significantly higher than those in subjects of previous reports, ranging from 20.68 to 23.35% of the total haemoglobin. The individuals had also 5-8% Hb F, consisting solely of alpha and Ggamma chains. Investigation of the distribution of Hb F among the red cells of Hb Kenya heterozygotes, using monospecific antibodies absorbed against pure Hb Kenya and rendered fluorescent by conjugation with fluorescein isothiocyanate, showed the presence of fetal haemoglobin in all red cells. The data suggest that the phenotype of the Hb Kenya trait resembles that of the Ggamma form of hereditary persistence of fetal haemoglobin rather than that of thalassaemia.
- Subjects :
- Male
Heterozygote
Hemoglobins, Abnormal
Biology
Antibodies
Chromatography, DEAE-Cellulose
Persistence (computer science)
Fusion gene
chemistry.chemical_compound
parasitic diseases
Haemoglobin F
Fetal haemoglobin
Humans
Electrophoresis, Paper
Uganda
Amino Acid Sequence
Fluorescein isothiocyanate
Fetal Hemoglobin
Genetics
Heterozygote advantage
Hematology
Molecular biology
Fluorescence
Kenya
Pedigree
Hemoglobinopathies
chemistry
biology.protein
Female
Antibody
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- British journal of haematology
- Accession number :
- edsair.doi.dedup.....033239e4c6daf5d9bbed78183ed3193b