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Landscape of immune cell gene expression is unique in predominantly WHO grade 1 skull base meningiomas when compared to convexity
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Modulation of tumor microenvironment is an emerging frontier for new therapeutics. However in meningiomas, the most frequent adult brain tumor, the correlation of microenvironment with tumor phenotype is scarcely studied. We applied a variety of systems biology approaches to bulk tumor transcriptomics to explore the immune environments of both skull base and convexity (hemispheric) meningiomas. We hypothesized that the more benign biology of skull base meningiomas parallels the relative composition and activity of immune cells that oppose tumor growth and/or survival. We firstly applied gene co-expression networks to tumor bulk transcriptomics from 107 meningiomas (derived from 3 independent studies) and found immune processes to be the sole biological mechanism correlated with anatomical location while correcting for tumour grade. We then derived tumor immune cell fractions from bulk transcriptomics data and examined the immune cell-cytokine interactions using a network-based approach. We demonstrate that oncolytic Gamma-Delta T cells dominate skull base meningiomas while mast cells and neutrophils, known to play a role in oncogenesis, show greater activity in convexity tumors. Our results are the first to suggest the importance of tumor microenvironment in meningioma biology in the context of anatomic location and immune landscape. These findings may help better inform surgical decision making and yield location-specific therapies through modulation of immune microenvironment.
- Subjects :
- Male
Neutrophils
T-Lymphocytes
Systems biology
Brain tumor
Gene Expression
lcsh:Medicine
Context (language use)
Biology
medicine.disease_cause
Skull Base Neoplasms
Article
Gene regulatory networks
Meningioma
Immune system
Target identification
Meningeal Neoplasms
Tumor Microenvironment
medicine
otorhinolaryngologic diseases
Humans
lcsh:Science
Skull Base
Tumor microenvironment
Multidisciplinary
Molecular medicine
Brain Neoplasms
lcsh:R
Brain
medicine.disease
Oncolytic virus
Cancer research
Gene ontology
Female
lcsh:Q
Neoplasm Grading
Transcriptome
Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....033cbdfa4abfb8aa294e741a6e2d50f9