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Evolution of autobiographical memory impairments in Alzheimer's disease and frontotemporal dementia - A longitudinal neuroimaging study
- Source :
- Neuropsychologia. 110
- Publication Year :
- 2016
-
Abstract
- Compromised autobiographical memory (ABM) retrieval is well established in dementia, attributable to degeneration of a core memory brain network. It remains unclear, however, how the progressive spread of atrophy with advancing disease severity impacts ABM retrieval across life epochs. To this end, we conducted a longitudinal study of recent and remote ABM in Alzheimer's disease (AD, n =11), and a frontotemporal lobar degeneration group (FTD, n =13) comprising 7 behavioral variant FTD and 6 semantic dementia patients, in comparison with 23 healthy older Controls. Patients were re-assessed approximately one year following their initial visit and underwent repeat testing and brain imaging. Linear mixed modeling neuroimaging analyses explored disease-specific cortical changes driving ABM alterations over time. AD patients showed comparable ABM profiles across assessment periods however, follow-up performance correlated strongly with lateral temporal lobe integrity. In contrast, recent ABMs were disproportionately disrupted at follow-up relative to baseline in the FTD group, attributable to cortical thinning in posterior brain regions, including the right posterior cingulate cortex. Our findings offer new insights regarding the potential time-specific role of discrete cortical regions in ABM retrieval and the differential fate of formerly evocative memories with advancing disease severity in dementia syndromes.
- Subjects :
- Male
Cognitive Neuroscience
Memory, Episodic
Semantic dementia
Experimental and Cognitive Psychology
Neuroimaging
050105 experimental psychology
Temporal lobe
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Alzheimer Disease
medicine
Dementia
Semantic memory
Humans
0501 psychology and cognitive sciences
Longitudinal Studies
Episodic memory
Aged
Memory Disorders
Autobiographical memory
05 social sciences
Brain
Frontotemporal lobar degeneration
Middle Aged
medicine.disease
Frontotemporal Dementia
Disease Progression
Female
Atrophy
Psychology
Neuroscience
030217 neurology & neurosurgery
Frontotemporal dementia
Follow-Up Studies
Subjects
Details
- ISSN :
- 18733514
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Neuropsychologia
- Accession number :
- edsair.doi.dedup.....034ab248411a33705adec8f984e2987e