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Growth Hormone and Hexarelin Prevent Endothelial Vasodilator Dysfunction in Aortic Rings of the Hypophysectomized Rat
- Source :
- Journal of Cardiovascular Pharmacology. 34:454-460
- Publication Year :
- 1999
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1999.
-
Abstract
- The endothelial vasodilation mechanism(s) has been investigated in aortic rings of hypophysectomized male rats as well as hypophysectomized rats treated for 7 days with growth hormone (GH, 400 microg/kg, s.c.) or hexarelin (80 microg/kg, s.c.). Tissue preparations from intact animals were taken as controls. The results obtained indicate that the release of 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) from aortic rings of hypophysectomized rats was markedly reduced (51%; p
- Subjects :
- Male
medicine.medical_specialty
Hypophysectomy
Endothelium
medicine.medical_treatment
Vasodilation
6-Ketoprostaglandin F1 alpha
Biology
Protective Agents
Rats, Sprague-Dawley
Internal medicine
medicine.artery
Homeostasi
medicine
Animals
Homeostasis
Humans
Enzyme Inhibitor
Enzyme Inhibitors
BIO/14 - FARMACOLOGIA
Aorta
Protective Agent
Pharmacology
omega-N-Methylarginine
Endothelin-1
Animal
Human Growth Hormone
Body Weight
Biological activity
Endothelin 1
Acetylcholine
Rats
Endocrinology
medicine.anatomical_structure
Circulatory system
Rat
Oligopeptide
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
Oligopeptides
Human
Blood vessel
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Pharmacology
- Accession number :
- edsair.doi.dedup.....035b32a455139aa12bf2f348be918c47