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Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?
- Source :
- PLoS ONE, PLoS ONE, Vol 5, Iss 9, p e12959 (2010), PLOS ONE, Vol. 5, No 9 (2010) P. e12959, Worbe, Yulia; Mallet, Luc; Golmard, Jean-Louis; Béhar, Cécile; Durif, Franck; Jalenques, Isabelle; Damier, Philippe; Derkinderen, Pascal; Pollak, Pierre; Anheim, Mathieu; Broussolle, Emannuel; Xie, Jing; Mesnage, Valérie; Mondon, Karl; Viallet, François; Jedynak, Pierre; Ben Djebara, Mouna; Schüpbach, Michael; Pelissolo, Antoine; Vidailhet, Marie; ... (2010). Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? PLoS ONE, 5(9), e12959. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0012959
- Publication Year :
- 2010
-
Abstract
- BackgroundRepetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.Methods166 consecutive patients with GTS aged 15-68 years were recruited and submitted to extensive neurological, psychiatric and psychological evaluations. RB were evaluated by the YBOCS symptom checklist and Mini International Neuropsychiatric Interview (M.I.N.I), and classified on the basis of a semi-directive psychiatric interview as compulsions or tics.ResultsRB were present in 64.4% of patients with GTS (107/166) and categorised into 3 major groups: a 'tic-like' group (24.3%-40/166) characterised by RB such as touching, counting, 'just right' and symmetry searching; an 'OCD-like' group (20.5%-34/166) with washing and checking rituals; and a 'mixed' group (13.2%-22/166) with both 'tics-like' and 'OCD-like' types of RB present in the same patient. In 6.3% of patients, RB could not be classified into any of these groups and were thus considered 'undetermined'.ConclusionsThe results confirm the phenomenological heterogeneity of RB in GTS patients and allows to distinguish two types: tic-like behaviours which are very likely an integral part of GTS; and OCD-like behaviours, which can be considered as a comorbid condition of GTS and were correlated with higher score of complex tics, neuroleptic and SSRIs treatment frequency and less successful socio-professional adaptation. We suggest that a meticulous semiological analysis of RB in GTS patients will help to tailor treatment and allow to better classify patients for future pathophysiologic studies.Trial registrationClinicalTrials.gov NCT00169351.
- Subjects :
- Adult
Male
medicine.medical_specialty
Obsessive-Compulsive Disorder
animal structures
Tics
Adolescent
Mental Health/Neuropsychiatric Disorders
Science
Biology
Tourette syndrome
Young Adult
mental disorders
medicine
Humans
Young adult
Psychiatry
Tourette Syndrome/diagnosis/psychology
Neurological Disorders/Movement Disorders
Mini-international neuropsychiatric interview
Aged
Neuroscience/Cognitive Neuroscience
Multidisciplinary
Middle Aged
medicine.disease
Tics/diagnosis/psychology
Obsessive-Compulsive Disorder/diagnosis/psychology
Psychological evaluation
ddc:616.8
Compulsive behavior
Compulsive Behavior
Anxiety
Medicine
Female
Psychiatric interview
medicine.symptom
Tourette Syndrome
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 5
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....03886d004ec3b5d7089eafa06d618d6a
- Full Text :
- https://doi.org/10.1371/journal.pone.0012959