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Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?

Authors :
Emannuel Broussolle
Karl Mondon
Jean Louis Golmard
Yves Agid
Pascal Derkinderen
François Viallet
Valérie Mesnage
Jing Xie
Andreas Hartmann
Luc Mallet
Pierre Jedynak
Michael Schüpbach
Mathieu Anheim
Franck Durif
Isabelle Jalenques
Yulia Worbe
Jean-Luc Houeto
Marie Vidailhet
C. Béhar
Antoine Pelissolo
Philippe Damier
Mouna Ben Djebara
Pierre Pollak
Source :
PLoS ONE, PLoS ONE, Vol 5, Iss 9, p e12959 (2010), PLOS ONE, Vol. 5, No 9 (2010) P. e12959, Worbe, Yulia; Mallet, Luc; Golmard, Jean-Louis; Béhar, Cécile; Durif, Franck; Jalenques, Isabelle; Damier, Philippe; Derkinderen, Pascal; Pollak, Pierre; Anheim, Mathieu; Broussolle, Emannuel; Xie, Jing; Mesnage, Valérie; Mondon, Karl; Viallet, François; Jedynak, Pierre; Ben Djebara, Mouna; Schüpbach, Michael; Pelissolo, Antoine; Vidailhet, Marie; ... (2010). Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? PLoS ONE, 5(9), e12959. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0012959
Publication Year :
2010

Abstract

BackgroundRepetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.Methods166 consecutive patients with GTS aged 15-68 years were recruited and submitted to extensive neurological, psychiatric and psychological evaluations. RB were evaluated by the YBOCS symptom checklist and Mini International Neuropsychiatric Interview (M.I.N.I), and classified on the basis of a semi-directive psychiatric interview as compulsions or tics.ResultsRB were present in 64.4% of patients with GTS (107/166) and categorised into 3 major groups: a 'tic-like' group (24.3%-40/166) characterised by RB such as touching, counting, 'just right' and symmetry searching; an 'OCD-like' group (20.5%-34/166) with washing and checking rituals; and a 'mixed' group (13.2%-22/166) with both 'tics-like' and 'OCD-like' types of RB present in the same patient. In 6.3% of patients, RB could not be classified into any of these groups and were thus considered 'undetermined'.ConclusionsThe results confirm the phenomenological heterogeneity of RB in GTS patients and allows to distinguish two types: tic-like behaviours which are very likely an integral part of GTS; and OCD-like behaviours, which can be considered as a comorbid condition of GTS and were correlated with higher score of complex tics, neuroleptic and SSRIs treatment frequency and less successful socio-professional adaptation. We suggest that a meticulous semiological analysis of RB in GTS patients will help to tailor treatment and allow to better classify patients for future pathophysiologic studies.Trial registrationClinicalTrials.gov NCT00169351.

Details

ISSN :
19326203
Volume :
5
Issue :
9
Database :
OpenAIRE
Journal :
PloS one
Accession number :
edsair.doi.dedup.....03886d004ec3b5d7089eafa06d618d6a
Full Text :
https://doi.org/10.1371/journal.pone.0012959