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Oncologists' and Cancer Patients' Views on Whole-Exome Sequencing and Incidental Findings: Results from The CanSeq Study
- Source :
- Genetics in medicine : official journal of the American College of Medical Genetics
- Publication Year :
- 2016
-
Abstract
- Although targeted sequencing improves outcomes for many cancer patients, it remains uncertain how somatic and germ-line whole-exome sequencing (WES) will integrate into care. We conducted surveys and interviews within a study of WES integration at an academic center to determine oncologists’ attitudes about WES and to identify lung and colorectal cancer patients’ preferences for learning WES findings. One-hundred sixty-seven patients (85% white, 58% female, mean age 60) and 27 oncologists (22% female) participated. Although oncologists had extensive experience ordering somatic tests (median 100/year), they had little experience ordering germ-line tests. Oncologists intended to disclose most WES results to patients but anticipated numerous challenges in using WES. Patients had moderately low levels of genetic knowledge (mean 4 correct out of 7). Most patients chose to learn results that could help select a clinical trial, pharmacogenetic and positive prognostic results, and results suggesting inherited predisposition to cancer and treatable noncancer conditions (all ≥95%). Fewer chose to receive negative prognostic results (84%) and results suggesting predisposition to untreatable noncancer conditions (85%). The majority of patients want most cancer-related and incidental WES results. Patients’ low levels of genetic knowledge and oncologists’ inexperience with large-scale sequencing present challenges to implementing paired WES in practice. Genet Med 18 10, 1011–1019.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Colorectal cancer
Bioinformatics
Article
Inherited Predisposition
03 medical and health sciences
0302 clinical medicine
Internal medicine
Neoplasms
medicine
cancer
Humans
Exome
Genetic Predisposition to Disease
Genetics (clinical)
Exome sequencing
Germ-Line Mutation
Aged
Oncologists
Incidental Findings
business.industry
Genome, Human
Cancer
High-Throughput Nucleotide Sequencing
sequencing
Middle Aged
medicine.disease
Prognosis
3. Good health
return of results
Clinical trial
030104 developmental biology
030220 oncology & carcinogenesis
Female
Return of results
business
Pharmacogenetics
Subjects
Details
- Language :
- English
- ISSN :
- 15300366 and 10983600
- Volume :
- 18
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Genetics in medicine : official journal of the American College of Medical Genetics
- Accession number :
- edsair.doi.dedup.....038eb3b48bf812e3ced1b9c204e90319