Supplementary Figures S1-S7 from Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer

Supplementary Figures S1-S7. Figure S1: Characterization of heterozygous P2rx7 +/- mice Figure S2: The A740003 pharmacological inhibitor of P2RX7 dampens colitis Figure S3: P2rx7-dependent colonic epithelial cell proliferation Figure S4: Scoring of pre-cancerous dysplasic lesions Figure S5: Body weight curves of WT, P2rx7-/- and A438079-treated mice on a CAC regimen Figure S6: Histological examination of cancerous colonic lesions of WT and P2rx7-/- mice Figure S7: The cancerous microenvironment of P2rx7-/- mice is enriched in neutrophils