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Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy

Authors :
Jing-Long Huang
Sui-Ling Liao
Man-Chin Hua
Chuan-Chi Kao
Shih-Yin Huang
Chi-Hsin Chiang
Kuan-Wen Su
Tsung-Chieh Yao
Kuo-Wei Yeh
Shen-Hao Lai
Ming-Han Tsai
Source :
Mediators of Inflammation, Vol 2016 (2016), Mediators of Inflammation
Publication Year :
2016
Publisher :
Hindawi Publishing Corporation, 2016.

Abstract

Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r=0.67,p<0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p=0.004) and TLR7-8 stimulation (p=0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.

Details

Language :
English
ISSN :
09629351
Database :
OpenAIRE
Journal :
Mediators of Inflammation
Accession number :
edsair.doi.dedup.....04234fa68286f22c1e3495aca6724696
Full Text :
https://doi.org/10.1155/2016/8175898