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Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy
- Source :
- Mediators of Inflammation, Vol 2016 (2016), Mediators of Inflammation
- Publication Year :
- 2016
- Publisher :
- Hindawi Publishing Corporation, 2016.
-
Abstract
- Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r=0.67,p<0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p=0.004) and TLR7-8 stimulation (p=0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.
- Subjects :
- Vitamin
Adult
Male
Cord
Article Subject
Immunology
Physiology
Ligands
Communicable Diseases
Monocytes
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Pregnancy
Vitamin D and neurology
lcsh:Pathology
Medicine
Humans
030212 general & internal medicine
Prospective Studies
Vitamin D
Prenatal vitamins
Fetus
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Toll-Like Receptors
Cell Biology
medicine.disease
Fetal Blood
Culture Media
Interleukin-10
030228 respiratory system
chemistry
Cord blood
Viruses
Female
business
Research Article
lcsh:RB1-214
Subjects
Details
- Language :
- English
- ISSN :
- 09629351
- Database :
- OpenAIRE
- Journal :
- Mediators of Inflammation
- Accession number :
- edsair.doi.dedup.....04234fa68286f22c1e3495aca6724696
- Full Text :
- https://doi.org/10.1155/2016/8175898