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Temporal exposure and consistency of endocrine disrupting chemicals in a longitudinal study of individuals with impaired fasting glucose
- Source :
- Environmental Research, 197:110901. ACADEMIC PRESS INC ELSEVIER SCIENCE, Environ Res
- Publication Year :
- 2021
-
Abstract
- Endocrine disrupting chemicals (EDCs) include non-persistent exogenous substances such as parabens, bisphenols and phthalates which have been associated with a range of metabolic disorders and disease. It is unclear if exposure remains consistent over time. We investigated change in indicators of EDC exposure between 2009 and 2016 and assessed its consistency between and within individuals over a median follow-up time of 47 months in a sample of Dutch individuals. Of 500 Dutch individuals, two 24 h urine samples were analysed for 5 parabens, 3 bisphenols and 13 metabolites of in total 8 different phthalates. We calculated per-year differences using metaanalysis and assessed temporal correlations between and within individuals using Spearman correlation coefficients, intra-class correlation coefficients (ICC) and kappa-statistics. We found a secular decrease in concentrations of methyl, ethyl, propyl and n-butyl paraben, bisphenol A, and metabolites of di-ethyl phthalate (DEP), di-butyl phthalate (DBP), di-(2-ethyl-hexyl) phthalate (DEHP), and butylbenzyl phthalate (DBzP) which varied from 8 to 96% (ethyl paraben, propyl paraben) between 2009 and 2016. Within-person temporal correlations were highest for parabens (ICC: 0.34 to 0.40) and poorest for bisphenols (ICC: 0.15 to 0.23). For phthalate metabolites, correlations decreased most between time periods (ICC < 48 months: 0.22 to 0.39; >= 48 months: 0.05 to 0.32). When categorizing EDC concentrations, 33-54% of individuals remained in the lowest or highest category and temporal correlations were similar to continuous measurements. Exposure to most EDCs decreased between 2009 and 2016 in a sample of individuals with impaired fasting glucose from the Dutch population. Temporal consistency was generally poor. The inconsistency in disease associations may be influenced by individual-level or temporal variation exhibited by EDCs. Our findings call for the need for repeated measurements of EDCs in observational studies before and during at-risk temporal windows for the disease.
- Subjects :
- medicine.medical_specialty
Bisphenol A
Longitudinal study
SAMPLES
BIOMARKERS
Phthalic Acids
Parabens
Urine
Bisphenols
010501 environmental sciences
Endocrine Disruptors
01 natural sciences
Biochemistry
Medical and Health Sciences
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Phthalates
Internal medicine
medicine
Endocrine system
Humans
030212 general & internal medicine
Longitudinal Studies
0105 earth and related environmental sciences
General Environmental Science
PROPYL PARABEN
RISK
Chemistry
Phthalate
NURSES HEALTH
WOMEN
Environmental Exposure
Fasting
ASSOCIATION
Impaired fasting glucose
medicine.disease
Reproducibility
Paraben
BISPHENOL-A
Endocrinology
Glucose
NHANES DATA
Temporal stability
Environmental Pollutants
Clinical Medicine
URINARY PHTHALATE METABOLITES
Subjects
Details
- Language :
- English
- ISSN :
- 00139351
- Database :
- OpenAIRE
- Journal :
- Environmental Research, 197:110901. ACADEMIC PRESS INC ELSEVIER SCIENCE, Environ Res
- Accession number :
- edsair.doi.dedup.....0428f880f85f694f41b6f6f5cde62d6f