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Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes

Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes

Authors :
Fumie Sakamoto
Keiko Fujisawa
Mitsuyoshi Takahara
Yoko Irie
Iichiro Shimomura
Toyoko Naka
Naoto Katakami
Taka-aki Matsuoka
Fumiyo Kubo
Kazuyuki Miyashita
Tetsuyuki Yasuda
Hideaki Kaneto
Source :
Atherosclerosis. 227:425-428
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects.

Details

ISSN :
00219150
Volume :
227
Database :
OpenAIRE
Journal :
Atherosclerosis
Accession number :
edsair.doi.dedup.....04300c618a49bdf8ab121ca7caf81019
Full Text :
https://doi.org/10.1016/j.atherosclerosis.2013.01.016