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Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes
Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes
- Source :
- Atherosclerosis. 227:425-428
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects.
- Subjects :
- Male
Cardiovascular event
medicine.medical_specialty
Time Factors
Receptor for Advanced Glycation End Products
Disease
Type 2 diabetes
Rage (emotion)
Gastroenterology
Diabetes Complications
Japan
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Prospective Studies
Receptors, Immunologic
Prospective cohort study
Aged
Proportional Hazards Models
Predictive biomarker
business.industry
Proportional hazards model
Middle Aged
Atherosclerosis
medicine.disease
Endocrinology
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Regression Analysis
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 227
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....04300c618a49bdf8ab121ca7caf81019
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2013.01.016