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Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum
- Source :
- Organic letters. 20(13)
- Publication Year :
- 2018
-
Abstract
- Citrofulvicin (1), along with its early shunt product fulvionol (2), was characterized as a skeletally unprecedented antiosteoporotic agent from a human sputum-derived fungus Penicillium velutinum. The unique citrofulvicin framework is likely formed by a nonenzymatic intermolecular Diels–Alder cycloaddition between heptaketide-based intermediates. Citrofulvicin and fulvionol were demonstrated to be osteogenic at 0.1 μM in the prednisolone-induced osteoporotic zebrafish.
- Subjects :
- 0301 basic medicine
biology
Cycloaddition Reaction
Molecular Structure
010405 organic chemistry
Chemistry
Stereochemistry
fungi
Organic Chemistry
Penicillium
biology.organism_classification
01 natural sciences
Biochemistry
Cycloaddition
0104 chemical sciences
03 medical and health sciences
Polyketide
030104 developmental biology
Polyketides
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 20
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....043a9cd78d23dc06643392a559ecea0f