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Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial
- Source :
- Wiener klinische Wochenschrift. 117:558-560
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- INTRODUCTION: Control of postoperative symptoms is of paramount importance in ambulatory surgery. This trial was conducted to evaluate whether a micronized purified flavonoid fraction (MPFF) (Detralex®) reduces postoperative bleeding, pain and consumption of analgesics after ambulatory stapled hemorrhoidopexy, as reported in trials after classic hemorrhoidectomy. Phlebotropic activity, protective effect on the capillaries and anti-inflammatory properties of this drug have been reported in several studies. METHODS: Sixty-three patients with third-degree hemorrhoids had ambulatory stapled hemorrhoidopexy under spinal anesthesia in the period of one year. The patients were randomized, with 30 receiving Detralex 500 mg (2 tablets 3 times daily for 5 days after the operation) and 33 forming the control group. The patients were asked to daily self-assess the presence of blood on defecation, degree of pain and consumption of analgesics for the first week after the operation. RESULTS: There was no significant difference between the two groups in duration of presence of blood, degree of pain or analgesics requirement. No major complications, such as bleeding requiring transfusion or hospitalization, sepsis, anal stenosis or urgent defecation, were noted in the follow-up period. There were no side effects from Detralex treatment. DISCUSSION: In our study we could not demonstrate any positive effect of prescribing flavonoids after stapler hemorrhoidopexy. This procedure may not be sufficiently aggressive and is associated with too few postoperative complications to show any protective influence of flavonoids.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Anti-Inflammatory Agents
Pelvic Pain
Hemorrhoids
law.invention
Sepsis
Melena
Randomized controlled trial
Anal stenosis
law
Surgical Stapling
Humans
Medicine
Intestinal Mucosa
Flavonoids
Analgesics
Pain, Postoperative
business.industry
Hesperidin
General Medicine
Middle Aged
medicine.disease
Surgery
Clinical trial
Drug Combinations
Treatment Outcome
Stapled hemorrhoidopexy
Anesthesia
Ambulatory
Diosmin
Defecation
Female
business
Subjects
Details
- ISSN :
- 16137671 and 00435325
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Wiener klinische Wochenschrift
- Accession number :
- edsair.doi.dedup.....048f36d80a804c640aa4456f01f4d252