Cataract in early onset and classic Cockayne syndrome

Purpose: To describe cataracts in classic and early onset Cockayne syndrome (CS). Classic CS typically has an onset after the first year of life; intrauterine growth failure and severe neurologic dysfunction from birth distinguishes the less common early onset CS from the classic form. Methods: A complete ophthalmic evaluation was performed in four affected patients, one with the early onset and three with classic c s. Results: We report cataract in all patients and glaucoma in one, the latter never previously reported in CS. Conclusion: CS should be considered in babies with low birth weight and congenital cataract.