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Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia
- Source :
- BMC Research Notes, BMC Research Notes, Vol 4, Iss 1, p 322 (2011)
- Publication Year :
- 2011
- Publisher :
- BioMed Central, 2011.
-
Abstract
- Background The current study was undertaken to determine the degree of activation of gallbladder mucosal mast cells, whether mast cell (MC) density or activation differ between patients with and without a positive clinical response to cholecystectomy, and whether either density or activation correlate with gallbladder emptying. Results Fifteen biliary dyskinesia (BD) and 13 symptomatic cholelithiasis (CL) patients undergoing cholecystectomy were prospectively enrolled. Gallbladder wall MC density (by immunohistochemistry) and activation (by electron microscopy) were determined. Clinical response was evaluated 30 days post-cholecystectomy on a 5-point Likert-type scale. A complete or nearly complete clinical response was seen in 100% of CL and in 87% of BD patients. The overall degranulation indices were 49.4 ± 18.7% for CL patients and 44.2 ± 16.8% for BD patients. Neither MC density nor activation correlated with the gallbladder ejection fraction. A complete clinical response was associated with lower epithelial MC density. Conclusion Cholecystectomy is efficacious in relieving pain in both CL and BD patients. BD and CL are associated not only with increased MC density but a moderate to high degree of MC activation. A possible relationship between MC density and outcome for BD warrants further investigation.
- Subjects :
- Pathology
medicine.medical_specialty
medicine.medical_treatment
lcsh:Medicine
Biliary dyskinesia
cholecystectomy
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
biliary dyskinesia
Internal medicine
medicine
lcsh:Science (General)
lcsh:QH301-705.5
Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Mast cell activation
business.industry
Gallbladder
lcsh:R
General Medicine
Gallstones
medicine.disease
Mast cell
medicine.anatomical_structure
lcsh:Biology (General)
Cholecystectomy
Gallbladder Emptying
business
mast cell
cholelithiasis
lcsh:Q1-390
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17560500
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- BMC Research Notes
- Accession number :
- edsair.doi.dedup.....049dfcb1cc30c284c5693ab3595df15e