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Prognostic value of admission serum magnesium in acute myocardial infarction complicated by malignant ventricular arrhythmias
- Source :
- The American Journal of Emergency Medicine. 44:100-105
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Although electrolyte abnormalities are related to worse clinical outcomes in patients with acute myocardial infarction (AMI), little is known about the association between admission serum magnesium level and adverse events in AMI patients complicated by out-of-hospital cardiac arrest presenting with malignant ventricular arrhythmias (OHCA-MVA). We investigated the prognostic value of serum magnesium level on admission in these patients.We retrospectively analyzed the data of 165 consecutive reperfused AMI patients complicated with OHCA-MVA between April 2007 and February 2020 in our university hospital. Serum magnesium concentration was measured on admission. The primary outcome was in-hospital death.Fifty-four patients (33%) died during hospitalization. Higher serum magnesium level was significantly related to in-hospital death (FineGray's test; p 0.001). In multivariable logistic regression analyses, serum magnesium level on admission was independently associated with in-hospital death (hazard ratio 2.68, 95% confidence interval 1.24-5.80) even after adjustment for covariates. Furthermore, the incidences of cardiogenic shock necessitating an intra-aortic balloon pump (p = 0.005) or extracorporeal membrane oxygenation (p 0.001), tracheal intubation (p 0.001) and persistent vegetative state (p = 0.002) were significantly higher in patients with higher serum magnesium level than in those with lower serum magnesium level.In reperfused AMI patients complicated by OHCA-MVA, admission serum magnesium level might be a potential surrogate marker for predicting in-hospital death.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
chemistry.chemical_element
Myocardial Reperfusion
Hospitals, University
03 medical and health sciences
0302 clinical medicine
Primary outcome
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
Magnesium
In patient
Hospital Mortality
cardiovascular diseases
Myocardial infarction
Adverse effect
Aged
Retrospective Studies
Surrogate endpoint
business.industry
Percutaneous coronary intervention
030208 emergency & critical care medicine
General Medicine
Magnesium level
Middle Aged
Prognosis
medicine.disease
chemistry
Ventricular Fibrillation
Tachycardia, Ventricular
Emergency Medicine
Cardiology
Female
business
Biomarkers
Out-of-Hospital Cardiac Arrest
Subjects
Details
- ISSN :
- 07356757
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- The American Journal of Emergency Medicine
- Accession number :
- edsair.doi.dedup.....049ed2ffac2bc9df12bdd22ea1478991