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Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California
- Source :
- International journal of environmental research and public health, vol 18, iss 19, International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health, Vol 18, Iss 10107, p 10107 (2021), Volume 18, Issue 19
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Acetaminophen is the most common over-the-counter pain and fever medication used by pregnant women. While European studies suggest acetaminophen exposure in pregnancy could affect childhood asthma development, findings are less consistent in other populations. We evaluated whether maternal prenatal acetaminophen use is associated with childhood asthmatic symptoms (asthma diagnosis, wheeze, dry cough) in a Los Angeles cohort of 1201 singleton births. We estimated risk ratio (RR) and 95% confidence interval (CI) for childhood asthmatic outcomes according to prenatal acetaminophen exposure. Effect modification by maternal race/ethnicity and psychosocial stress during pregnancy was evaluated. The risks for asthma diagnosis (RR = 1.39, 95% CI 0.96, 2.00), wheezing (RR = 1.25, 95% CI 1.01, 1.54) and dry cough (RR =1.35, 95% CI 1.06, 1.73) were higher in children born to mothers who ever used acetaminophen during pregnancy compared with non-users. Black/African American and Asian/Pacific Islander children showed a greater than two-fold risk for asthma diagnosis and wheezing associated with the exposure. High maternal psychosocial stress also modified the exposure-outcome relationships. Acetaminophen exposure during pregnancy was associated with childhood asthmatic symptoms among vulnerable subgroups in this cohort. A larger study that assessed prenatal acetaminophen exposure with other social/environmental stressors and clinically confirmed outcomes is needed.
- Subjects :
- Pediatrics
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Reproductive health and childbirth
Toxicology
Article
Pregnancy
childhood asthma
Clinical Research
Wheeze
medicine
Humans
Conditions Affecting the Embryonic and Fetal Periods
Child
Lung
Asthma
Respiratory Sounds
acetaminophen
Pediatric
business.industry
Prevention
Public Health, Environmental and Occupational Health
race/ethnicity
race/ethnicity & nbsp
Perinatal Period - Conditions Originating in Perinatal Period
medicine.disease
Los Angeles
Confidence interval
Acetaminophen
Relative risk
Prenatal Exposure Delayed Effects
Cohort
Respiratory
Pacific islanders
Medicine
Female
psychosocial stress
medicine.symptom
business
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- International journal of environmental research and public health, vol 18, iss 19, International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health, Vol 18, Iss 10107, p 10107 (2021), Volume 18, Issue 19
- Accession number :
- edsair.doi.dedup.....04aabbdf8581a621ab5d8ce633d4ea5d