Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico

This study evaluated the association of −401C/T and +452C/T polymorphisms of γ-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the −401C/T polymorphism and the risk of relapse was found (p = 0.028), patients with the −401T/T genotype have 10.83 (95% CI 1.30–90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the −401C/T polymorphism in the γ-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL.