Back to Search
Start Over
Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors
- Source :
- Bioorganicmedicinal chemistry letters. 9(19)
- Publication Year :
- 1999
-
Abstract
- A novel series of hydroxamate/urea-based inhibitors of gelatinases has been discovered via solid-phase combinatorial chemistry. SAR of P1′, P2′, and P3′ has been exploited and structures different from traditional succinate-based MMP inhibitors have been found.
- Subjects :
- Gelatinases
Clinical Biochemistry
Gelatinase A
Pharmaceutical Science
Peptide
Matrix Metalloproteinase Inhibitors
Hydroxamic Acids
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Drug Discovery
Urea
Enzyme Inhibitors
Molecular Biology
chemistry.chemical_classification
Hydroxamic acid
biology
Molecular Structure
Organic Chemistry
Enzyme
chemistry
Enzyme inhibitor
Drug Design
biology.protein
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 9
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....04b8e6e68a17ba45b1ddb1ef665767b6