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Decline in drawing ability and cerebral perfusion in Parkinson's disease patients after subthalamic nucleus deep brain stimulation surgery
- Source :
- Parkinsonismrelated disorders. 70
- Publication Year :
- 2018
-
Abstract
- Background Subthalamic nucleus deep brain stimulation (STN DBS) is an established therapy for alleviating motor symptoms in advanced Parkinson's disease (PD) patients; however, a postoperative decline in cognitive and speech function has become problematic although its mechanism remains unclear. The aim of the present study was to elucidate the properties of language and drawing ability and cerebral perfusion in PD patients after bilateral STN DBS surgery. Methods Western aphasia battery, including drawing as a subcategory, and perfusion (N-isopropyl-p-[123I] iodoamphetamine) SPECT scan was conducted in 21 consecutive PD patients , before, and three to six months after, bilateral STN DBS surgery while on stimulation. Perfusion images were compared with those of 17 age- and gender-matched healthy volunteers. In the parametric image analysis, the statistical peak threshold was set at P Results Although motor symptoms were improved and general cognition was preserved in the patient group, 11 patients (52.4%) showed a decline in the drawing subcategory after surgery, which showed a reduction in Frontal Assessment Battery score in this group of patients. Statistical parametric analysis of the brain perfusion images showed a decrease of cerebral blood flow in the prefrontal and cingulate cortex after surgery. Patients whose drawing ability declined showed decreased perfusion in the middle cingulate cortex comparing before and after surgery. Conclusion Present results show that some PD patients show a decline in drawing ability after bilateral STN DBS which may attributable by dysfunction in the cingulate network.
- Subjects :
- 0301 basic medicine
Cingulate cortex
Male
medicine.medical_specialty
Parkinson's disease
Deep brain stimulation
medicine.medical_treatment
Deep Brain Stimulation
Prefrontal Cortex
Perfusion scanning
Gyrus Cinguli
03 medical and health sciences
0302 clinical medicine
Subthalamic Nucleus
Medicine
Humans
Cerebral perfusion pressure
Western Aphasia Battery
Aged
Tomography, Emission-Computed, Single-Photon
business.industry
Parkinson Disease
Middle Aged
medicine.disease
Surgery
030104 developmental biology
Treatment Outcome
Neurology
Cerebral blood flow
Cerebrovascular Circulation
Female
Neurology (clinical)
Geriatrics and Gerontology
business
Perfusion
030217 neurology & neurosurgery
Psychomotor Performance
Follow-Up Studies
Subjects
Details
- ISSN :
- 18735126
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Parkinsonismrelated disorders
- Accession number :
- edsair.doi.dedup.....04c84c3e02298ba6ce7640eeb56f96f9