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Influence of the pH Value of Refluxate and Proximal Extent on Heartburn Perception in Patients with Proton Pump Inhibitor-Refractory Non-Erosive Reflux Disease
- Source :
- Digestion. 101:375-381
- Publication Year :
- 2019
- Publisher :
- S. Karger AG, 2019.
-
Abstract
- Background and Objectives: Weakly acidic reflux has been reported as the major cause of symptom occurrence in patients with proton pump inhibitor (PPI)-refractory non-erosive reflux disease (NERD). This study is aimed at clarifying whether the pH value of weakly acidic reflux affects the induction of symptoms. Methods: We retrospectively evaluated the records of combined multichannel intraluminal impedance and pH monitoring in 57 patients with PPI-refractory NERD. Weakly acidic refluxes were divided into 3 categories based on the pH value of the refluxate: pH 4–5, 5–6, and 6–7. Results: A total of 29 patients were positive in the symptom index. The symptom provocation rate in reflux of pH 4–5 (19%) was much higher than in that of pH 5–6 (11%) and pH 6–7 (12%). In the reflux at pH 4–5, the symptom provocation rate in the proximal reflux was higher than that in the distal reflux (p < 0.05), whereas the reflux at pH 5–6 and pH 6–7 was not significantly different in the symptom provocation rate between the proximal and distal refluxes. Conclusion: Reflux at pH
- Subjects :
- Male
Impedance–pH monitoring
medicine.medical_specialty
Esophageal pH Monitoring
medicine.drug_class
Nerd
Proton-pump inhibitor
Ph monitoring
Gastroenterology
03 medical and health sciences
Esophagus
0302 clinical medicine
Heartburn
Refractory
Internal medicine
Electric Impedance
medicine
Humans
In patient
Treatment Failure
Retrospective Studies
business.industry
digestive, oral, and skin physiology
Reflux
Proton Pump Inhibitors
Hydrogen-Ion Concentration
Middle Aged
Symptom Flare Up
Gastrointestinal Contents
digestive system diseases
030220 oncology & carcinogenesis
Gastroesophageal Reflux
Female
Perception
030211 gastroenterology & hepatology
Symptom Assessment
medicine.symptom
business
Subjects
Details
- ISSN :
- 14219867 and 00122823
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Digestion
- Accession number :
- edsair.doi.dedup.....04c88d452fc9c651e44f06cd55a544be