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Frequent Klebsiella pneumoniae Urinary Tract Infections in a Patient Treated with Ruxolitinib
- Source :
- Antibiotics, Vol 8, Iss 3, p 150 (2019), Antibiotics
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Ruxolitinib is a targeted agent that inhibits Janus 2 Kinase and is approved for use in Polycythemia Vera and Primary Myelofibrosis. Its mechanism of action involves inhibition of cellular proliferation via the Janus kinase/signal transducer and activator of transcription proteins pathway. Ruxolitinib has different immune modulating effects that result in functional immunosuppression, leading to an increased susceptibility to certain infections. Klebsiella pneumoniae infections, in particular, were common among the reported pathogens contracted by ruxolitinib users. We report a 75-year-old male patient who had recurrent K. pneumoniae urinary tract infections while on ruxolitinib for Polycythemia Vera. This case is reported to add to the literature describing an increased susceptibility of patients to this often-resistant bacteria and to raise awareness about the immune modulating effects of JAK inhibitors.
- Subjects :
- Microbiology (medical)
Ruxolitinib
Klebsiella pneumoniae
medicine.medical_treatment
JAK kinase (Janus Kinase)
Case Report
Biochemistry
Microbiology
03 medical and health sciences
0302 clinical medicine
Polycythemia vera
Immune system
STAT (Signal Transducer and Activator of Transcription proteins) kinase
hemic and lymphatic diseases
Medicine
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Immunemodulation
Myelofibrosis
Klebsiella pneumonia
biology
business.industry
lcsh:RM1-950
Immunosuppression
biology.organism_classification
medicine.disease
Infectious Diseases
lcsh:Therapeutics. Pharmacology
030220 oncology & carcinogenesis
Immunology
STAT protein
business
Janus kinase
030215 immunology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20796382
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Antibiotics
- Accession number :
- edsair.doi.dedup.....04dd98a9486619943520c81a2ab3caa0