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The ICln interactome
- Publication Year :
- 2006
- Publisher :
- Blackwell Publishing, 2006.
-
Abstract
- The many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one-protein-one-function base. Therefore, the study of the interactome of the different proteins is of utmost importance. Here, we describe the present knowledge of the ICln interactome. ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a 'connector hub' with 'date hub' function.
- Subjects :
- Proteomics
Genetics
Binding Sites
Rna processing
Physiology
Cells
Cell Membrane
Computational biology
Biology
Interactome
Genome
Phenotype
Settore BIO/09 - Fisiologia
Ion Channels
Structure-Activity Relationship
Humans
Ion Channel Gating
Ion channel
Function (biology)
Signal Transduction
Methylosome
ICln
Interactomics
Ion channels
RNA-processing
Volume regulation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....050e4ad7e0791d5ad19c3c4ade2bede6