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A facile approach to fabricate self-assembled magnetic nanotheranostics for drug delivery and imaging
- Source :
- Nanoscale, vol 10, iss 46
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- Superparamagnetic iron oxide (SPIO) nanoparticles were extensively employed for theranostic applications, due to their good biocompatibility and excellent magnetic resonance imaging (MRI) properties. However, these particles typically require surface modification due to their hydrophobic surfaces caused by the oil-phase surfactants used in the fabrication and the drug loading on their surface is usually limited. Here, we provided a novel and facile approach to conveniently perform surface modification of SPIO while simultaneously loading a large amount of drug. By synthesizing an amphiphilic irinotecan-based compound, which hydrophobic tail enabled to insert into the SPIOs assembly, an excellent SPIO-based theranostic nanomedicine (SPIO@IR) was formed. The SPIO@IR can not only extensively improve the drug efficacy, but also enable to visualize themselves by MRI in the biological system.
- Subjects :
- Technology
Materials science
Theranostic Nanomedicine
Biocompatibility
Transplantation, Heterologous
Nanoparticle
Contrast Media
Nanotechnology
Bioengineering
02 engineering and technology
010402 general chemistry
Irinotecan
01 natural sciences
Ferric Compounds
Article
Self assembled
Mice
Amphiphile
Animals
Humans
General Materials Science
Particle Size
Nanoscience & Nanotechnology
Magnetite Nanoparticles
Drug Carriers
Microscopy
Transplantation
Heterologous
Microscopy, Confocal
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
0104 chemical sciences
5.1 Pharmaceuticals
Confocal
Drug delivery
Colonic Neoplasms
Physical Sciences
Chemical Sciences
Surface modification
Biomedical Imaging
Development of treatments and therapeutic interventions
0210 nano-technology
HT29 Cells
Hydrophobic and Hydrophilic Interactions
Biotechnology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nanoscale, vol 10, iss 46
- Accession number :
- edsair.doi.dedup.....05219f900d2c13169dd223ef8f45cb4a