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Results of a Pilot Randomized Placebo-Controlled Trial in Primary and Secondary Raynaud's Phenomenon with St. John's Wort: Detecting Changes in Angiogenic Cytokines When RP Improves
Results of a Pilot Randomized Placebo-Controlled Trial in Primary and Secondary Raynaud's Phenomenon with St. John's Wort: Detecting Changes in Angiogenic Cytokines When RP Improves
- Source :
- ISRN Rheumatology
- Publication Year :
- 2011
- Publisher :
- International Scholarly Research Network, 2011.
-
Abstract
- Objectives.To perform a 6-week double-blind RCT in Raynaud's phenomenon (RP) comparing the plant extract St. John's Wort (SJW) to placebo. Methods. RP patients having at least 7 attacks per week were stratified by primary and secondary RP and within secondary by systemic sclerosis or other connective tissue disease. Subjects completed a daily standardized diary recording all RP attacks (frequency, duration and severity). Serum levels of 18 inflammatory and angiogenic cytokines were measured pre- and post-treatment. Results. Eighteen patients completed the study; 8 received SJW and 10 placebo. The decrease in mean number of attacks per day was 0.75 with SJW and 1.01 with placebo, P=0.06. Attack duration and severity were not different between groups. Cytokine analyses demonstrated no between-groups differences. Combining treatment groups, those with >50% improvement in frequency of attacks yielded a significant increase in E-selectin (P=0.049), MMP-9 (P=0.011), G-CSF (P=0.02), and VEGF (P=0.012) pre- versus post-treatment. A ≥50% improvement in severity of attacks corresponded to a significant increase in levels of sVCAM-1 (P=0.003), sICAM-1 (P=0.007), and MCP-1 (P=0.004). Conclusions. There were no clinical or biomarker benefit of SJW versus placebo in RP. However, combining all patients, there were changes in some cytokines that may be further investigated.
- Subjects :
- Secondary Raynaud's Phenomenon
medicine.medical_specialty
biology
Article Subject
business.industry
medicine.medical_treatment
VEGF receptors
Placebo-controlled study
Placebo
medicine.disease
Connective tissue disease
law.invention
Surgery
Cytokine
Randomized controlled trial
law
Internal medicine
medicine
biology.protein
Biomarker (medicine)
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20905475 and 20905467
- Volume :
- 2011
- Database :
- OpenAIRE
- Journal :
- ISRN Rheumatology
- Accession number :
- edsair.doi.dedup.....05241de00c3fa12f7cad92cc33f1c01e