The interferon-induced MxB protein inhibits an early step of HIV-1 infection

Authors :: Fengwen Xu
Jin Qian
Chen Liang
Shan Cen
Shilei Ding
Zhenlong Liu
Fei Guo
Jinming Zhou
Qinghua Pan
Source :: Retrovirology
Publication Year :: 2013
Publisher :: Springer Science and Business Media LLC, 2013.
Abstract: Background Interferon protects cells from virus infection by inducing the expression of genes with antiviral activities. One such antiviral gene is Mx (myxovirus resistance) that was first identified in mice for its protection against influenza virus infection. Humans carry two Mx genes, MxA and MxB. Although MxA has been reported to inhibit a number of RNA and DNA viruses, the antiviral function of MxB has just begun to be revealed.