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Glycoprotein A (GARP) in children who outgrow food allergy
- Source :
- Allergologia et Immunopathologia. 48:67-72
- Publication Year :
- 2020
- Publisher :
- Codon Publications, 2020.
-
Abstract
- There is little understanding of the mechanisms by which food allergy (FA) develops into persistent disease, or by which symptoms it regresses. Food allergy is a major health problem in developed countries, where the prevalence reaches up to 6% in children and 3% in the adult population.Children with food allergy remission (FAR) and those without FAR below five years of age, were compared 7-10 years with respect to clinical data and expression of glycoprotein A repetitions predominant (GARP) on peripheral blood mononuclear cells.Forty children with FAR and 40 children without FAR at age 7-10, in whom FA was previously diagnosed at age below five years were evaluated. In this prospective study, demographic and clinical data were taken, patients were classified as atopic based on history and serum specific IgE (sIgE) for a specific allergen. Blood samples were obtained from all patients to assess expression of GARP.We observed higher expression of GARP in children with FAR compared to children without FA (p=0.005); optimal cut-off for GARP prediction of the remission was 20.1%. Children with FAR and food-specific IgE in serum had higher expression of GARP compared to children with low food specific IgE (0.35kU/L). Keeping pets at home decreased, and presence of allergic rhinitis increased ORs for high expression of GARP (hGARP) in our patients.hGARP (20.1%) is related with FAR in school children. Allergic rhinitis, and pets at home modify this effect of GARP. Children with allergic rhinitis have less chance of developing remission despite maintaining immune tolerance (hGARP); quite the opposite case with pets at home.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Remission, Spontaneous
Immunology
Immunoglobulin E
medicine.disease_cause
Peripheral blood mononuclear cell
Immune tolerance
03 medical and health sciences
0302 clinical medicine
Allergen
Food allergy
Internal medicine
Immune Tolerance
medicine
Animals
Humans
Immunology and Allergy
Prospective Studies
Child
Prospective cohort study
Serum specific ige
biology
business.industry
Membrane Proteins
Pets
General Medicine
Allergens
medicine.disease
Rhinitis, Allergic
030228 respiratory system
Leukocytes, Mononuclear
biology.protein
Female
Food specific IgE
business
Food Hypersensitivity
030215 immunology
Subjects
Details
- ISSN :
- 03010546
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Allergologia et Immunopathologia
- Accession number :
- edsair.doi.dedup.....0550541379b619602ad03c012c66ecd1
- Full Text :
- https://doi.org/10.1016/j.aller.2019.06.008