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Influence of serum vitamin D level in the response of actinic keratosis to ingenol mebutate

Authors :
Ricardo Moreno‐Alonso de Celada
Tamara Gracia‐Cazaña
Laura Najera‐Botello
Paulina Cerro‐Muñoz
Angeles Juarranz
Salvador Gonzalez
Yolanda Gilaberte
Source :
Dermatologic therapyREFERENCES.
Publication Year :
2022

Abstract

Vitamin D (VD) serum levels, and keratinocytic basal expression of vitamin D receptor (VDR) before treatment of actinic keratoses (AK) have been previously reported as possible biomarkers of the response of AK to treatments. We intended to evaluate the association between these and other serum and immunohistochemical parameters with the response of AK to treatment with topical ingenol mebutate (IM). Twenty-five patients with AK on the head were treated with topical IM 0.015% gel once daily for 3 days. Biopsies were taken at baseline and 6 weeks after treatment. Immunohistochemical staining was performed for VDR, P53, Ki67, Aurora B, Survivin and β-catenin. Basal serum 25(OH)D levels were determined. IM was more effective for KIN I and II AKs than in KIN III, and histological responders showed significantly higher serum VD levels (30.278 [SD 8.839] ng/mL) than nonresponders (21.14 [SD 7.079] ng/mL, p = 0.023). In addition, mean basal expression of VDR (45.63 [SD 16.105] %) increased significantly (57.92 [SD 14.738] %, p = 0.003) after treatment with IM. A significant decrease after treatment in the expression of several markers of aggressiveness and progression to squamous cell carcinoma, namely P53, Ki-67, aurora B kinase and survivin, was also observed. Our results support a relationship between VD status and the response of AK to treatment with topical IM, suggesting that its previous correction to proper serum levels in VD-deficient patients could improve the response of AK to the treatment.

Subjects

Subjects :
Dermatology
General Medicine

Details

ISSN :
15298019
Database :
OpenAIRE
Journal :
Dermatologic therapyREFERENCES
Accession number :
edsair.doi.dedup.....0552f5702a1b938904a299021a9686d3