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AGEs-related dysfunctions in PCOS: evidence from animal and clinical research
- Source :
- Journal of Endocrinology. 251:R1-R9
- Publication Year :
- 2021
- Publisher :
- Bioscientifica, 2021.
-
Abstract
- Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder in women in their reproductive age. In recent years, the role of advanced glycation end products (AGEs) in PCOS has gained great attention. AGEs are highly reactive molecules that can be assumed by diet or endogenously synthesized as by-products of metabolic processes. AGE deposition increases with aging, hyperglycemia, insulin resistance, and glycotoxin-rich diet. Therefore, it has become imperative to understand the underlying mechanism of AGEs actions and its downstream effects in PCOS pathophysiology. By integrating evidence from human studies and experimental models, the present review points out that altered AGE deposition is a common feature in all PCOS phenotypes. Searching for possible mechanisms involved in the adaptive response against glycation injury in oocytes and ovaries, the role of SIRT1, the main member of the mammalian sirtuin family, has also recently emerged. Therefore, further studies based on anti-AGE interventions could be helpful in creating innovative strategies for counteracting PCOS and its effects on fertility.
- Subjects :
- Glycation End Products, Advanced
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Bioinformatics
Endocrinology
Insulin resistance
Glycation
Internal medicine
medicine
Animals
Humans
Endocrine system
biology
Mechanism (biology)
business.industry
Polycystic ovary syndrome (PCOS)
medicine.disease
Polycystic ovary
Clinical research
Sirtuin
biology.protein
Female
business
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 14796805 and 00220795
- Volume :
- 251
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....055888a42570e743b43c48b4efc8698d