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Survival analysis of patients with subglottic squamous cell carcinoma based on the SEER database
- Source :
- Brazilian Journal of Otorhinolaryngology. 88:S70-S80
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Objective This study aimed to investigate the demographic and clinicopathological characteristics, and survival outcomes of subglottic Squamous Cell Carcinoma (SCC) based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods Demographic and clinicopathological information, including age, sex, race, tumor size, histologic grade, clinical/TNM stage, tumor invasion extent, Lymph Node Metastasis (LNM) extent, size of metastatic lymph nodes, LNM ratio and treatment data, of 842 subglottic SCC patients diagnosed between 1996 and 2016 were acquired. Kaplan-Meier survival analyses were performed to assess the effects of clinicopathological characteristics, treatment modalities, surgical procedures, and adjuvant therapies on overall survival and cancer-specific survival. Results Subglottic SCC was more frequent among males aged 60-70 years, with low-grade but locally advanced lesions without local or distant metastases. Age and several primary tumor/LNM related variables were independent risk factors for overall survival and cancer specific survival. Advanced-stage and high-grade disease led to unfavorable prognosis. The most common treatment modality and surgical procedure were surgery plus radiotherapy and total laryngectomy, respectively. Surgery plus radiotherapy provided favorable 5-year survival outcomes, while total laryngectomy had the worst. Surgery plus adjuvant therapy showed better survival outcomes than surgery alone. Conclusion This study confirmed the rarity of subglottic SCC. Patients with subglottic SCCs suffered poor prognosis especially for those with advanced-stage or high-grade lesions. The prognosis of subglottic SCC remained poor over the years, despite recent progress in cancer therapies. Surgery plus adjuvant therapy improved the survival outcome. Although larynx preservation surgery was beneficial for early-stage disease, total laryngectomy was favored for patients with advanced tumors. Level of evidence Level 4.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Subglottic Squamous Cell Carcinoma
medicine.medical_treatment
Kaplan-Meier Estimate
Internal medicine
medicine
Adjuvant therapy
Humans
Stage (cooking)
Laryngeal Neoplasms
Survival analysis
Retrospective Studies
Neoplasm Staging
Squamous Cell Carcinoma of Head and Neck
business.industry
Cancer
Prognosis
medicine.disease
Survival Analysis
Primary tumor
Survival Rate
Laryngectomy
Radiation therapy
Otorhinolaryngology
Head and Neck Neoplasms
Lymphatic Metastasis
Carcinoma, Squamous Cell
business
Subjects
Details
- ISSN :
- 18088694
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Otorhinolaryngology
- Accession number :
- edsair.doi.dedup.....056236d0c8c6e62e05124edbc60194f7