Back to Search Start Over

Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome

Authors :
Neus Baena
Assumpta Caixàs
Susanna Esteba-Castillo
Mercedes Rigla
Marina Viñas-Jornet
Miriam Guitart
Ramón Coronas
David Torrents-Rodas
Raquel Corripio
Olga Giménez-Palop
Marta Bueno
Joan Deus
Jesús Pujol
Elisabeth Gabau
Ramon Novell
Caixàs i Pedragós, Assumpta
Source :
Repositorio Abierto de la UdL, Universitad de Lleida, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS ONE, Recercat: Dipósit de la Recerca de Catalunya, Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya), PLoS ONE, Vol 11, Iss 9, p e0163468 (2016)
Publication Year :
2016
Publisher :
Public Library of Science, 2016.

Abstract

Context: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. Objectives: To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. Design: Experimental study. Setting: University hospital. Subjects: 90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese controls; and 30 age-sex-matched lean controls. Interventions: Subjects ingested a liquid meal after fasting ≥10 hours. Main Outcome Measures: Leptin and BDNF levels in plasma extracted before ingestion and 30’, 60’, and 120’ after ingestion. Hunger, measured on a 100-point visual analogue scale before ingestion and 60’ and 120’ after ingestion. Results: Fasting BDNF levels were lower in PWS than in controls (p = 0.05). Postprandially, PWS patients showed only a truncated early peak in BDNF, and their BDNF levels at 60' and 120' were lower compared with lean controls (p

Details

Database :
OpenAIRE
Journal :
Repositorio Abierto de la UdL, Universitad de Lleida, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS ONE, Recercat: Dipósit de la Recerca de Catalunya, Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya), PLoS ONE, Vol 11, Iss 9, p e0163468 (2016)
Accession number :
edsair.doi.dedup.....056b561fddfa88bd8db397ea9787d4fc