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Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome
- Source :
- Repositorio Abierto de la UdL, Universitad de Lleida, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS ONE, Recercat: Dipósit de la Recerca de Catalunya, Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya), PLoS ONE, Vol 11, Iss 9, p e0163468 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, 2016.
-
Abstract
- Context: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. Objectives: To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. Design: Experimental study. Setting: University hospital. Subjects: 90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese controls; and 30 age-sex-matched lean controls. Interventions: Subjects ingested a liquid meal after fasting ≥10 hours. Main Outcome Measures: Leptin and BDNF levels in plasma extracted before ingestion and 30’, 60’, and 120’ after ingestion. Hunger, measured on a 100-point visual analogue scale before ingestion and 60’ and 120’ after ingestion. Results: Fasting BDNF levels were lower in PWS than in controls (p = 0.05). Postprandially, PWS patients showed only a truncated early peak in BDNF, and their BDNF levels at 60' and 120' were lower compared with lean controls (p
- Subjects :
- 0301 basic medicine
Leptin
Physiology
Peptide Hormones
lcsh:Medicine
Biochemistry
Energy homeostasis
Body Mass Index
Endocrinology
0302 clinical medicine
Neurotrophic factors
Ingestion
Insulin
Homeostasis
Childhood obesity
lcsh:Science
Body mass index
Prader-Willi, Síndrome de
Multidisciplinary
digestive, oral, and skin physiology
Uniparental disomy
Postprandial
Physiological Parameters
Prader-Willi syndrome
Prader-Willi Syndrome
Research Article
medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
Childhood Obesity
030209 endocrinology & metabolism
Context (language use)
03 medical and health sciences
Internal medicine
medicine
Clinical genetics
Obesity
Growth hormone
Medicine and health sciences
Diabetic Endocrinology
Brain-derived neurotrophic factor
business.industry
lcsh:R
Body Weight
Biology and Life Sciences
nutritional and metabolic diseases
medicine.disease
Hormones
030104 developmental biology
Disorders of imprinting
Growth Hormone
lcsh:Q
Physiological Processes
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositorio Abierto de la UdL, Universitad de Lleida, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Recercat. Dipósit de la Recerca de Catalunya, instname, PLoS ONE, Recercat: Dipósit de la Recerca de Catalunya, Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya), PLoS ONE, Vol 11, Iss 9, p e0163468 (2016)
- Accession number :
- edsair.doi.dedup.....056b561fddfa88bd8db397ea9787d4fc