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Methicillin-resistant Staphylococcus aureus bacteraemia and endocarditis treated with ceftaroline salvage therapy
- Source :
- Journal of Antimicrobial Chemotherapy. 67:1267-1270
- Publication Year :
- 2012
- Publisher :
- Oxford University Press (OUP), 2012.
-
Abstract
- Background One of the newest methicillin-resistant Staphylococcus aureus (MRSA) antibiotics to receive FDA approval is ceftaroline fosamil, a member of a new subclass of cephalosporins with unique activity against MRSA. However, ceftaroline is currently only FDA approved for complicated skin/soft tissue infections and community-acquired pneumonia; there are currently no clinical data regarding its use in MRSA bacteraemia and endocarditis. We report a series of six patients in which ceftaroline was utilized as salvage monotherapy in persistent MRSA bacteraemia or endocarditis. Methods Using pharmacy records, 11 ceftaroline-treated patients were identified between January 2011 and November 2011 at University Health System and the South Texas Veterans Health Care System in San Antonio, TX, USA. All cases were reviewed and six patients received ceftaroline therapy for MRSA bacteraemia or endocarditis due to persistent or recurrent bacteraemia while on standard antibiotics (vancomycin or daptomycin). Results All six patients experienced rapid clearance of their bacteraemia after starting ceftaroline. In the case of endocarditis for which the patient subsequently developed heart failure and required valve replacement, there was no evidence of growth from cultures taken from the excised valve, suggesting sterilization within 13 days of starting ceftaroline. Conclusions Ceftaroline exhibits potent anti-MRSA activity in both in vitro and animal studies, including rabbit endocarditis models; however, the lack of clinical data has limited its use in bacteraemia and endovascular infections in humans. We hope that this series serves as an initial stepping stone for further evaluation of this compound for more invasive infections due to MRSA.
- Subjects :
- Adult
Male
Methicillin-Resistant Staphylococcus aureus
Microbiology (medical)
medicine.medical_specialty
medicine.drug_class
Antibiotics
Salvage therapy
Bacteremia
medicine.disease_cause
Internal medicine
medicine
Humans
Ceftaroline fosamil
Endocarditis
Pharmacology (medical)
Salvage Therapy
Pharmacology
business.industry
Endocarditis, Bacterial
Middle Aged
Staphylococcal Infections
bacterial infections and mycoses
medicine.disease
Texas
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
Cephalosporins
Treatment Outcome
Infectious Diseases
Vancomycin
Female
Daptomycin
business
medicine.drug
Subjects
Details
- ISSN :
- 14602091 and 03057453
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Journal of Antimicrobial Chemotherapy
- Accession number :
- edsair.doi.dedup.....0579be36399d3abc55423a8bdc85fe57