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The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia
- Source :
- Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 19(9)
- Publication Year :
- 2017
-
Abstract
- Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases. Clinical progress in targeting the endosteal niche is also discussed.
- Subjects :
- 0301 basic medicine
Cancer Research
Chemokine
Niche
Metastasis
03 medical and health sciences
Bone Marrow
medicine
Animals
Humans
Stem Cell Niche
Leukemia
Osteoblasts
biology
Hematopoietic stem cell
Osteoblast
General Medicine
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Cell Transformation, Neoplastic
Oncology
Immunology
biology.protein
Cancer research
Bone marrow
Signal transduction
Subjects
Details
- ISSN :
- 16993055
- Volume :
- 19
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
- Accession number :
- edsair.doi.dedup.....05ac7360a78312216ecba19c5c711968