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Characterizing behavioral and cognitive dysexecutive changes in progressive supranuclear palsy
- Source :
- Movement Disorders. 21:199-207
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale-Relatives (KAS-R), an instrument first developed to assess dysexecutive changes in head-injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS-R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodegenerative disease.
- Subjects :
- Male
Subcortical dementia
Prefrontal Cortex
Neuropsychological Tests
Personality Assessment
Gyrus Cinguli
Developmental psychology
Progressive supranuclear palsy
Reaction Time
medicine
Humans
Verbal fluency test
Attention
Apathy
Affective Symptoms
skin and connective tissue diseases
Problem Solving
Aged
Neurologic Examination
Dysexecutive syndrome
Verbal Behavior
Mental Disorders
Neuropsychology
Cognitive flexibility
Awareness
Middle Aged
medicine.disease
Frontal Lobe
Neurology
Frontal lobe
Set, Psychology
Female
Supranuclear Palsy, Progressive
sense organs
Neurology (clinical)
medicine.symptom
Cognition Disorders
Psychology
Clinical psychology
Subjects
Details
- ISSN :
- 15318257 and 08853185
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Movement Disorders
- Accession number :
- edsair.doi.dedup.....05be6a5c885e510cf12feb0ab32f8693