Back to Search
Start Over
Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1
- Source :
- Oncology Reports
- Publication Year :
- 2017
-
Abstract
- Lung cancer is the most common cause of cancer-associated mortality. MicroRNAs (miRNAs), as oncogenes or tumor suppressor genes, serve crucial roles not only in tumorigenesis, but also in tumor invasion and metastasis. Although miRNA-let-7a (let-7a) has been reported to suppress cell growth in multiple cancer types, the biological mechanisms of let-7a in lung adenocarcinoma are yet to be fully elucidated. In the present study, the molecular roles of let-7a in lung adenocarcinoma were investigated by detecting its expression in lung adenocarcinoma tissues and exploring its roles in the regulation of lung cancer cell proliferation. Let-7a expression was identified to be downregulated in lung adenocarcinoma tissues compared with normal tissues. Overexpression of let-7a effectively suppressed cancer cell proliferation, migration and invasion in H1299 and A549 cells. Let-7a also induced cell apoptosis and cell cycle arrest. Furthermore, let-7a significantly inhibited cell growth by directly regulating cyclin D1 signals. This novel regulatory mechanism of let-7a in lung adenocarcinoma provides possible avenues for future targeted therapies of lung cancer.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Lung Neoplasms
cyclin D1
Apoptosis
medicine.disease_cause
Metastasis
0302 clinical medicine
Cell Movement
Tumor Cells, Cultured
let-7a
General Medicine
Articles
Cell cycle
respiratory system
Middle Aged
Prognosis
Gene Expression Regulation, Neoplastic
Survival Rate
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Signal Transduction
Adult
Biology
03 medical and health sciences
medicine
Biomarkers, Tumor
Humans
metastasis
Neoplasm Invasiveness
Lung cancer
non-small cell lung cancer
Aged
Cell Proliferation
Oncogene
Cell growth
Cancer
Cell Cycle Checkpoints
medicine.disease
respiratory tract diseases
MicroRNAs
030104 developmental biology
Case-Control Studies
Cancer research
Carcinogenesis
Follow-Up Studies
Subjects
Details
- ISSN :
- 17912431
- Volume :
- 40
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....05e25ed8991fd7c0fce4ede2adae68f9