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Differential proto-oncogene mRNA induction from rats treated with peroxisome proliferators
- Source :
- Biochemical and Biophysical Research Communications. 173:855-861
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- After experimental treatment of rats with clofibrate or ciprofibrate, two peroxisomes proliferators with hypolipidemic activity, RNAs were prepared from liver, kidney, heart and brain; hybridization was done with DNA probes for c-myc and c-Ha-ras oncogenes and for cyanide insensitive Acyl CoA oxidase, a peroxisomal protein. c-myc mRNA is highly abundant in liver and at a lower extent in kidney, especially after treatment with ciprofibrate; clofibrate also allows a c-myc mRNA increase, but at a lower extent. c-Ha-ras, which is already expressed in all tested tissues from control animals, is stimulated by clofibrate and ciprofibrate treatments. Comparatively these compounds stimulate the cyanide insensitive Acyl CoA oxidase expression as well as they increase the somatic index of liver and kidney. From these experiments we suggest that hepatocarcinogenesis triggered by some hyolipidemic agents could be mediated by proto-oncogene mRNA level increase.
- Subjects :
- Male
Somatic cell
Genes, myc
Biophysics
Biology
Kidney
Microbodies
Biochemistry
Clofibric Acid
Proto-Oncogenes
medicine
Animals
Acyl-CoA oxidase
Clofibrate
RNA, Messenger
Molecular Biology
Hypolipidemic Agents
Messenger RNA
Oncogene
Fibric Acids
Cell Biology
Peroxisome
Molecular biology
Rats, Inbred F344
Rats
Genes, ras
medicine.anatomical_structure
Gene Expression Regulation
Liver
Organ Specificity
Acyl-CoA Oxidase
Ciprofibrate
Oxidoreductases
medicine.drug
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 173
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....05e37fbf5f60d6f6b9c2eb5babc5d7f2