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Glycodelin A triggers T cell apoptosis through a novel calcium-independent galactose-binding lectin activity
- Source :
- Molecular immunology. 46(16)
- Publication Year :
- 2008
-
Abstract
- Glycodelin A (GdA) is one of the progesterone inducible endometrial factors that protect the fetal semiallograft from maternal immune rejection. The immumoregulatory effects of GdA are varied, with diverse effects on the fate and function of most immune cell types. Its effects on T cells are particularly relevant as it is capable of regulating T cell activation, differentiation, as well as apoptosis. We have previously reported that GdA triggers mitochondrial stress and apoptosis in activated T cells by a mechanism that is distinct and independent of its effects on T cell activation. In this study we describe the characterization of a cell surface receptor for GdA on T cells. Our results reveal a novel calcium-independent galactose-binding lectin activity of GdA, which is responsible for its apoptogenic function. This discovery adds GdA to a select group of soluble immunoregulatory lectins that operate within the feto-placental compartment, the only other members being the galectin family proteins. We also report for the first time that both CD4(+) and CD8(+) T cell subsets are equally susceptible to inhibition with GdA, mediated by its novel lectin activity. We demonstrate that GdA selectively recognizes complex-type N-linked glycans on T cell surface glycoproteins. and propose that the galectin-1 glycoprotein receptor CD7 maybe a novel target for GdA on T cells. This study, for the first time, links the lectin activity of GdA to its biological function.
- Subjects :
- CD4-Positive T-Lymphocytes
Galectin 1
T cell
Placenta
Immunology
Apoptosis
Antigens, CD7
Biology
CD8-Positive T-Lymphocytes
Pregnancy Proteins
Lymphocyte Activation
Jurkat cells
Biochemistry
Jurkat Cells
Immune system
Fetus
Cell surface receptor
medicine
Animals
Humans
Receptor
Molecular Biology
Galectin
Glycoproteins
Cell biology
Mitochondria
medicine.anatomical_structure
Glycodelin
Galectin-1
Cattle
Female
K562 Cells
CD8
Subjects
Details
- ISSN :
- 18729142
- Volume :
- 46
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular immunology
- Accession number :
- edsair.doi.dedup.....05e93032a6a369abedadf8f23383ca21