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A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems
- Source :
- Materials, Volume 12, Issue 23
- Publication Year :
- 2019
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2019.
-
Abstract
- A well-dispersed SiO2@Layered hydroxide cupric benzoate (SiO2@Cu-LBMS) with a hierarchical structure have been synthesized by a facile method. The layered hydroxide cupric benzoate with a structure of layered basic metal salt (Cu-LBMS) was directly deposited on the surface of silica spheres without any blinder. The morphology of the SiO2@Cu-LBMS nano-microsphere was observed by SEM, and the reaction conditions was also discussed. In addition, the XRD patterns and FTIR spectra provide consistent evidence to the formation of SiO2@Cu-LBMS nano-microspheres. The release behavior and drug loading capability of SiO2@Cu-LBMS microspheres were also investigated by using ibuprofen, aspirin and salicylic acid as model drugs. The results indicated that the drug loading capability of SiO2@Cu-LBMS nano-microspheres was much larger than layered hydroxide cupric benzoate, and the releasing time was significantly prolonged than layered hydroxide cupric benzoate and their physical mixture.
- Subjects :
- Drug
Morphology (linguistics)
media_common.quotation_subject
Salt (chemistry)
02 engineering and technology
010402 general chemistry
01 natural sciences
Metal
chemistry.chemical_compound
Nano
medicine
General Materials Science
sustained release
media_common
chemistry.chemical_classification
layered hydroxide cupric benzoate
021001 nanoscience & nanotechnology
Ibuprofen
0104 chemical sciences
SiO2@Cu-LBMS
chemistry
Chemical engineering
visual_art
visual_art.visual_art_medium
Hydroxide
0210 nano-technology
drug loading capability
Salicylic acid
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19961944
- Database :
- OpenAIRE
- Journal :
- Materials
- Accession number :
- edsair.doi.dedup.....05e9e583d4f171a84ab4c36c91bf05bc
- Full Text :
- https://doi.org/10.3390/ma12233978