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Very Low-Calorie Ketogenic Diet: a safe and effective tool for weight loss in patients with obesity and mild kidney failure
- Source :
- Nutrients, Nutrients, Vol 12, Iss 2, p 333 (2020), Volume 12, Issue 2
- Publication Year :
- 2020
-
Abstract
- Very low-calorie ketogenic diets (VLCKD) are an effective and increasingly used tool for weight loss. Traditionally considered high protein, ketogenic diets are often looked at with concern by clinicians due to the potential harm they pose to kidney function. We herein evaluated the efficacy and safety of a VLCKD in patients with obesity and mild kidney failure. A prospective observational real-life study was conducted on ninety-two patients following a VLCKD for approximately 3 months. Thirty-eight had mild kidney failure and fifty-four had no renal condition and were therefore designated as control. Anthropometric parameters, bioelectrical impedance and biochemistry data were collected before and at the end of the dietary intervention. The average weight loss was nearly 20% of initial weight, with a significant reduction in fat mass. We report an improvement of metabolic parameters and no clinically relevant variation regarding liver and kidney function. Upon stratification based on kidney function, no differences in the efficacy and safety outcomes were found. Interestingly, 27.7% of patients with mild renal failure reported normalization of glomerular filtrate after dietary intervention. We conclude that, when conducted under the supervision of healthcare professionals, a VLCKD is an effective and safe treatment for weight loss in patients with obesity, including those affected by mild kidney failure.
- Subjects :
- Male
very low energy diet
medicine.medical_treatment
High-protein diet
medicine.disease_cause
0302 clinical medicine
Weight loss
high protein diet
VLCD
Renal Insufficiency
030212 general & internal medicine
kidney function
Kidney
Nutrition and Dietetics
Middle Aged
VLCKD
Very low calorie diet
medicine.anatomical_structure
Female
medicine.symptom
Diet, Ketogenic
lcsh:Nutrition. Foods and food supply
Bioelectrical impedance analysis
safety
Adult
medicine.medical_specialty
low carbohydrate diet
food.diet
Renal function
lcsh:TX341-641
030209 endocrinology & metabolism
Article
03 medical and health sciences
food
Internal medicine
Weight Loss
chronic kidney disease
very low-calorie diet
renal function
medicine
Humans
Obesity
Caloric Restriction
business.industry
medicine.disease
business
Food Science
Ketogenic diet
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nutrients, Nutrients, Vol 12, Iss 2, p 333 (2020), Volume 12, Issue 2
- Accession number :
- edsair.doi.dedup.....05f37c54f8c76a0903492f8a134ba2bc