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Data from Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

Data from Estrogen Induces Repression of the Breast Cancer and Salivary Gland Expression Gene in an Estrogen Receptor α–Dependent Manner

Authors :
Stefanie Denger
Frank Gannon
Michael J. Kerin
Aoife J. Lowery
Nicola Miller
Heike Brand
Nancy Bretschneider
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function as a breast cancer marker. In MCF7 cells, BASE is repressed by estrogen in an estrogen receptor α (ERα)-dependent manner. Promoter analysis of the BASE gene led to the identification of a 2-kb upstream enhancer that harbors binding sites for ERα and FoxA1. The recruitment of both ERα and FoxA1 to this region was shown by chromatin immunoprecipitation analysis. Furthermore, mutation studies and knockdown experiments show a clear separation between gene expression mediated by FoxA1 and ERα-dependent gene regulation. Additionally, we provide information on BASE expression in human breast tumor samples. [Cancer Res 2008;68(1):106–14]

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....0604fa0975c74683f9cf46305fed25e2
Full Text :
https://doi.org/10.1158/0008-5472.c.6496574.v1