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Identification of Environmental Risk Factors Associated With the Development of Inflammatory Bowel Disease
- Source :
- Journal of Crohn's and Colitis, 14(12), 1662-1671. Oxford University Press
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background and AimsMultiple genetic and environmental factors are involved in the aetiology of inflammatory bowel disease [IBD] including Crohn’s disease [CD] and ulcerative colitis [UC], but data on these exposome factors are difficult to identify. Several exposome factors such as smoking have been shown to be involved; as for other environmental factors, eg stress, results have been conflicting.MethodsWe performed a case-control study including 674 IBD patients of the 1000IBD cohort, frequency-matched based on sex and age with 1348 controls from the population-based Lifelines Cohort Study. Exposome data were obtained using the validated Groningen IBD Environmental Questionnaire [GIEQ], capturing exposome factors through different stages of life using 844 items, of which 454 were applicable to study the role of 93 exposome factors in disease aetiology. Logistic regression [LR] modelling with Bonferroni correction for multiple testing was applied to estimate the multivariable-adjusted effect of each exposome factor.ResultsFor IBD, we identified four novel factors: stressful life events (CD odds ratio [OR] 2.61/UC OR 2.92), high perceived stress [2.29/2.67], alcohol use [0.40/0.43], and bronchial hyper-reactivity [3.04/2.36]. Four novel factors were associated with only CD: prenatal smoke exposure [1.89], having a bed partner [0.53], allergies [2.66], and cow’s milk hypersensitivity [5.87]; and two solely with UC: carpet flooring [0.57] and neuroticism [1.32]. Nine factors were replicated.ConclusionsIn this study we identified 10 novel, and replicated nine previously reported, exposome factors associated with IBD. Identifying these factors is important for both understanding disease aetiology and future prevention strategies to decrease the development of IBD in genetically susceptible persons.
- Subjects :
- Adult
Male
Exposome
medicine.medical_specialty
Disease
Inflammatory bowel disease
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Surveys and Questionnaires
Internal medicine
Odds Ratio
Humans
Medicine
030212 general & internal medicine
Irritable bowel syndrome
business.industry
Gastroenterology
Environmental Exposure
General Medicine
Middle Aged
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
Logistic Models
Case-Control Studies
Cohort
Etiology
Female
030211 gastroenterology & hepatology
business
Cohort study
Subjects
Details
- ISSN :
- 18764479 and 18739946
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Crohn's and Colitis
- Accession number :
- edsair.doi.dedup.....060fe60f2225b58e845f66381c819be1