Back to Search
Start Over
Understanding the roles of activation threshold and infections in the dynamics of autoimmune disease
- Source :
- Journal of Theoretical Biology. 375:13-20
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Onset and development of autoimmunity have been attributed to a number of factors, including genetic predisposition, age and different environmental factors. In this paper we discuss mathematical models of autoimmunity with an emphasis on two particular aspects of immune dynamics: breakdown of immune tolerance in response to an infection with a pathogen, and interactions between T cells with different activation thresholds. We illustrate how the explicit account of T cells with different activation thresholds provides a viable model of immune dynamics able to reproduce several types of immune behaviour, including normal clearance of infection, emergence of a chronic state, and development of a recurrent infection with autoimmunity. We discuss a number of open research problems that can be addressed within the same modelling framework.
- Subjects :
- Statistics and Probability
Recurrent infections
T-Lymphocytes
Autoimmunity
Thymus Gland
Biology
Lymphocyte Activation
medicine.disease_cause
Models, Biological
General Biochemistry, Genetics and Molecular Biology
Autoimmune Diseases
Immune tolerance
Mice
Immune system
Immune Tolerance
medicine
Genetic predisposition
Animals
Humans
Genetic Predisposition to Disease
Autoimmune disease
Stochastic Processes
General Immunology and Microbiology
Applied Mathematics
General Medicine
medicine.disease
Mice, Inbred C57BL
Chronic disease
Modeling and Simulation
Chronic Disease
Immunology
Lymphocyte activation
General Agricultural and Biological Sciences
Subjects
Details
- ISSN :
- 00225193
- Volume :
- 375
- Database :
- OpenAIRE
- Journal :
- Journal of Theoretical Biology
- Accession number :
- edsair.doi.dedup.....063cf0b8ef03ba2d63850eb65f295c74