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New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement
- Source :
- International journal of cardiology. 265
- Publication Year :
- 2018
-
Abstract
- Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endothelial dysfunction, and clinical implications including effects of interventions and cardiovascular events. To shorten and simplify the measurement of FMD, we have developed a novel technique named short time FMD (stFMD). We investigated the validity of stFMD for assessment of endothelial function compared with conventional FMD.We evaluated stFMD and conventional FMD in 82 subjects including patients with atherosclerotic risk factors and cardiovascular disease (66 men and 16 women, 57 ± 16 years). Both stFMD and conventional FMD were significantly correlated with age, systolic blood pressure, diastolic blood pressure and baseline brachial artery diameter. In addition, stFMD was significantly correlated with conventional FMD (r = 0.76, P 0.001). Bland-Altman plot analysis showed good agreement b etween stFMD and conventional FMD. Moreover, stFMD in the at risk group and that in the cardiovascular disease group were significantly lower than that in the no risk group (4.6 ± 2.3% and 4.4 ± 2.2% vs. 7.3 ± 1.9%, P 0.001, respectively). Optimal cutoff value of stFMD for diagnosing atherosclerosis was 7.0% (sensitivity of 71.0% and specificity of 85.0%).These findings suggest that measurement of stFMD, a novel and simple method, is useful for assessing endothelial function. Measurement of stFMD may be suitable for screening of atherosclerosis when repeated measurements of vascular function are required and when performing a clinical trial using a large population.URL for Clinical Trial: http://UMIN; Registration Number for Clinical Trial: UMIN000025458.
- Subjects :
- Novel technique
Adult
Male
medicine.medical_specialty
Time Factors
Brachial Artery
Vasodilation
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
medicine.artery
Internal medicine
medicine
Laser-Doppler Flowmetry
Humans
030212 general & internal medicine
Brachial artery
Endothelial dysfunction
Aged
business.industry
Middle Aged
medicine.disease
Clinical trial
Blood pressure
Cardiovascular Diseases
Regional Blood Flow
cardiovascular system
Cardiology
Female
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Vascular function
Blood Flow Velocity
Flow-Mediated Vasodilation
Subjects
Details
- ISSN :
- 18741754
- Volume :
- 265
- Database :
- OpenAIRE
- Journal :
- International journal of cardiology
- Accession number :
- edsair.doi.dedup.....06547bb216d501c43408071b2f9a5b24