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The molecular and cellular insight into the toxicology of bortezomib-induced peripheral neuropathy
- Source :
- Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 112068-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The proteasome inhibitor bortezomib (BTZ) is a first-line antitumor drug, mainly used for multiple myeloma treatment. However, BTZ shows prominent toxicity in the peripheral nervous system, termed BTZ-induced peripheral neuropathy (BIPN). BIPN is characterized by neuropathic pain, resulting in a dose reduction or even treatment withdrawal. To date, the pathological mechanism of BIPN has not been elucidated. There is still no effective strategy to prevent or treat BIPN. This review summarizes the pathological mechanisms of BIPN, which involves the pathological changes of Schwann cells, neurons, astrocytes and macrophages. A better knowledge of the pathological mechanisms of BIPN would provide new ideas for therapeutic interventions of BIPN patients.
- Subjects :
- Drug
media_common.quotation_subject
Antineoplastic Agents
RM1-950
Bortezomib
medicine
Animals
Humans
Schwann cells
Pathological
Multiple myeloma
media_common
Neurons
Pharmacology
business.industry
Macrophages
Peripheral Nervous System Diseases
Pathological mechanisms
General Medicine
medicine.disease
Peripheral neuropathy
medicine.anatomical_structure
Astrocytes
Peripheral nervous system
Neuropathic pain
Proteasome inhibitor
Cancer research
Bortezomib-induced peripheral neuropathy
Therapeutics. Pharmacology
Multiple Myeloma
business
Proteasome Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 07533322
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....06591a8edcb6bc0d459003e97b851da1